The urokinase receptor and the regulation of cell proliferation

Roberta Mazzieri; Francesco Blasi

doi:10.1160/TH05-01-0021

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 93(04): 641-646
DOI: 10.1160/TH05-01-0021

Theme Issue Article

Schattauer GmbH

The urokinase receptor and the regulation of cell proliferation

Authors

Roberta Mazzieri

¹Universita’ Vita-Salute San Raffaele and IFOM (FIRC Institute of Molecular Oncology), Milan, Italy
Francesco Blasi

¹Universita’ Vita-Salute San Raffaele and IFOM (FIRC Institute of Molecular Oncology), Milan, Italy

Abstract

Summary

The urokinase receptor is a multifunctional receptor modulating both proteolytic dependent and independent processes. It binds the extracellular proteolytic enzyme urokinase and engages lateral interactions with several transmembrane receptors, including integrins and the EGFR. Both, by initiating a proteolytic cascade acting on the extracellular matrix components, and by regulating the activity of important signal transducers, uPAR participates not only in the modulation of cell-cell and cell-extracellular matrix interactions, but also in the control of extracellular signals determining the proliferative state of a cell. Alteration of such a complex and finely modulated mechanism results in unregulated cell proliferation and altered tissue organization, typically associated with tumor progression.

Keywords

Urokinase receptor - proliferation - tumors - metastasis

Volltext

Referenzen

References
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