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Thromb Haemost 2005; 94(05): 975-979
DOI: 10.1160/TH05-05-0316
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Plasma concentrations and importance of high mobility group box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation

Tsuyoshi Hatada
1   Department of Emergency Medicine, Mie University School of Medicine, Mie, Japan
,
Hideo Wada
2   Department of Laboratory Medicine, Mie University School of Medicine, Mie, Japan
,
Tsutomu Nobori
2   Department of Laboratory Medicine, Mie University School of Medicine, Mie, Japan
,
Kazuhiro Okabayashi
3   Department of Anesthesiology, Mie University School of Medicine, Mie, Japan
,
Kazuo Maruyama
3   Department of Anesthesiology, Mie University School of Medicine, Mie, Japan
,
Yasunori Abe
4   Department of Central Laboratory, Mie University School of Medicine, Mie, Japan
,
Shinji Uemoto
5   First Department of Surgery, Mie University School of Medicine, Mie, Japan
,
Shingo Yamada
6   Central Institute, Shino-Test Co., Tokyo, Japan
,
Ikuro Maruyama
7   Vascular medicine, Kagoshima University Graduate School and Dental Science, Kagoshima, Japan
› Author Affiliations Financial support:This work was supported, in part, by a Grant-in-Aid from the Ministry of Education, Science, and Culture, Japan and a Grant-in-Aid for Blood Coagulation Abnormalities from the Ministry of Health and Welfare of Japan.
Further Information

Publication History

Received: 09 May 2005

Accepted after revision: 02 August 2005

Publication Date:
14 December 2017 (online)

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Summary

High Mobility Group Box chromosomal protein 1 (HMGB1) is a nuclear DNA-binding protein acting as a proinflammatory cytokine when released in the extracellular space from necrotic cells, activated macrophages and dendritic cells. HMGB1 acts on a specific receptor, RAGE (receptor for advanced glycation endproducts), and induces prolonged inflammation, organ failure, septicaemia and death. The aim of the study was to determine the diagnostic value of plasma HMGB1 concentration and its role in the development of organ failure in patients with disseminated intravascular coagulation (DIC). Plasma HMGB-1 levels were measured in patients with suspected DIC and their relationships with DIC, organ failure and clinical outcome were determined. The study took place at the intensive care facility, Mie University School of Medicine and comprised 201 patients with suspected DIC. Plasma HMGB1 was below the detection limit in normal subjects, but moderately elevated in patients with infectious diseases (4.54 ± 8.18 ng/ml, mean±SD), malignancies (2.15 ± 5.34 ng/ml), and traumas (6.47 ± 13.13 ng/ml). DIC was associated with significantly high plasma HMGB1 (14.05 ± 12.56 ng/ml) in these patients. The highest HMGBI levels were in patients with organ failure (8.29 ± 10.99 ng/ml) and non-survivors (16.58 ± 11.01 ng/ml). HMGB1 plasma levels correlated with the DIC score and sepsis-related organ failure assessment (SOFA) score. In conclusion, our data suggest that HMGB-1 is a potentially suitable prognostic marker of OF or DIC.

Keywords

HMGB-1 - DIC - organ failure
 

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