Thrombolysis in fulminant purpura: Observations on changes in microcirculatory perfusion during succesful treatment

Peter E. Spronk; Johannes H. Rommes; Cees Schaar; Can Ince

doi:10.1160/TH05-11-0746

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2006; 95(03): 576-578
DOI: 10.1160/TH05-11-0746

Case Report

Schattauer GmbH

Thrombolysis in fulminant purpura: Observations on changes in microcirculatory perfusion during succesful treatment

Peter E. Spronk

¹Departments of Intensive Care, Apeldoorn, The Netherlands

³Department of Physiology, Academic Medical Center, Amsterdam, The Netherlands

,

Johannes H. Rommes

¹Departments of Intensive Care, Apeldoorn, The Netherlands

,

Cees Schaar

²Internal Medicine, Gelre Hospitals, Lukas Site, Apeldoorn, The Netherlands

,

Can Ince

³Department of Physiology, Academic Medical Center, Amsterdam, The Netherlands

References
1 Gando S, Kameue T, Matsuda N. et al. Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma. Thromb Haemost 2002; 88: 943-9.
2 Fourrier F, Chopin C, Goudemand J. et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992; 101: 816-23.
3 Altamura M, Caradonna L, Amati L. et al. Splenectomy and sepsis: the role of the spleen in the immunemediated bacterial clearance. Immunopharmacol Immunotoxicol 2001; 23: 153-61.
4 Mathura KR, Vollebregt KC, Boer K. et al. Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol 2001; 91: 74-8.
5 Boerma C, Mathura KR, van der Voort PH. et al. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care 2005; 22: R601-R606.
6 Spronk PE, Ince C, Gardien MJ. et al. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002; 360: 1395-6.
7 De Backer D, Creteur J, Preiser JC. et al. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002; 166: 98-104.
8 Devictor D, Checoury A, Fries F. et al. [Prevention of distal necrosis in purpura fulminans. Value of sodium nitroprusside and urokinase]. Arch Fr Pediatr 1980; 37: 421-422 French.
9 Keeley SR, Matthews NT, Buist M. Tissue plasminogen activator for gangrene in fulminant meningococcaemia. Lancet 1991; 337: 1359.
10 Knofler R, Dinger J, Kabus M. et al. Thrombolytic therapy in children--clinical experiences with recombinant tissue-plasminogen activator. Semin Thromb Hemost 2001; 27: 169-74.
11 Aiuto LT, Barone SR, Cohen PS. et al. Recombinant tissue plasminogen activator restores perfusion in meningococcal purpura fulminans. Crit Care Med 1997; 25: 1079-82.
12 Pechlaner C, Buratti T, Biedermann H. et al. Thrombolytic therapy in adult meningococcal purpura fulminans with acute renal failure and severe perfusion deficits to the extremities. Wien Klin Wochenschr 1999; 111: 650-4.
13 Veldman A, Ehrenberg A, Jager G. et al. Is recombinant tissue plasminogen activator an option in the treatment of meningococcus-induced purpura?. Crit Care Med 2000; 28: 598-600.