Does a coxib-associated thrombotic risk limit the clinical use of the compounds as analgesic, antiinflammatory drugs?

Artur-Aron Weber; Thomas Hohlfeld; Sebastian Harder

doi:10.1160/TH06-08-0445

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2006; 96(04): 413-416
DOI: 10.1160/TH06-08-0445

Theme Issue Article

Schattauer GmbH

Does a coxib-associated thrombotic risk limit the clinical use of the compounds as analgesic, antiinflammatory drugs?

Arguments against

Authors

Artur-Aron Weber

¹Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
Thomas Hohlfeld

¹Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
Sebastian Harder

²Institut für Klinische Pharmakologie, Johann-Wolfgang Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany

Abstract

Summary

The issue of the risk-benefit assessment of cyclooxygenase-2 (COX-2) inhibitors, as compared to traditional non-steroidal anti-inflammatory drugs (tNSAIDs), is far from being resolved. These compounds need to be carefully re-evaluated in order to avoid hasty conclusions, as it happened when COX-2 inhibitors were introduced into clinical practice. Several arguments support the concept, that COX-2 inhibitors remain a valuable therapeutic option at least for selected patients.

Keywords

Arterial thrombosis - lipid mediators - inflammation - haemostasis - clinical studies

Full Text

References

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