Inflammatory profile of oxidized phospholipids

Valery N. Bochkov

doi:10.1160/TH06-08-0474

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 97(03): 348-354
DOI: 10.1160/TH06-08-0474

Theme Issue Article

Schattauer GmbH

Inflammatory profile of oxidized phospholipids

Valery N. Bochkov

¹Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria

› Author Affiliations

Abstract

Summary

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammatory and tissue-protective mechanisms. Thus, depending on the biological situation, OxPL can either stimulate or inhibit inflammation. In this review, the inflammatory properties of OxPL are discussed together with the underlying receptor, signalling and transcriptional mechanisms.

Keywords

Endothelial cells - phospholipids - inflammation

Full Text

References

References
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