Models for reaction mechanisms in haemostasis – Contributions from the study of prothrombin activation

Craig M. Jackson

doi:10.1160/TH07-04-0253

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(01): 24-35
DOI: 10.1160/TH07-04-0253

Anniversary Issue Contribution

Schattauer GmbH

Models for reaction mechanisms in haemostasis – Contributions from the study of prothrombin activation

Authors

Craig M. Jackson

¹Hemosaga Diagnostics Corp, San Diego, California, USA

Abstract

Summary

A brief history of the development of the contemporary model for the mechanism of prothrombin activation is presented.The focus is on the advances in understanding structure-function relationships in the molecules that comprise “prothrombinase” that occurred primarily during the 1970s. A link between the “classical theory” of hemostasis and the conceptual development of activation complexes as the activators of the precursors of coagulation proteases is developed. It is argued that advances occurred when new ideas arose that could be tested and new technologies enabled more definitive experiments to be performed.

Keywords

Prothrombinase - prothrombin - structure-function - coagulation models - models - history

Full Text

References

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