Interleukin 6 plasma levels predict with high sensitivity and specificity coronary stenosis detected by coronary angiography

Davide Noto; Santina Cottone; Angelo Baldassare Cefalù; Anna Vadalà; Carlo Maria Barbagallo; Manfredi Rizzo; Vincenzo Pernice; Mariangela Minà; Francesca Fayer; Giovanni Cerasola; Alberto Notarbartolo; Maurizio Rocco Averna

doi:10.1160/TH07-06-0414

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2007; 98(06): 1362-1367
DOI: 10.1160/TH07-06-0414

New Technologies, Diagnostic Tools and Drugs

Schattauer GmbH

Interleukin 6 plasma levels predict with high sensitivity and specificity coronary stenosis detected by coronary angiography

Authors

Davide Noto^*

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Santina Cottone^*

²Department of Internal Medicine, Cardiovascular and Nephro-urologic Diseases, University of Palermo, Palermo, Italy
Angelo Baldassare Cefalù

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Anna Vadalà

²Department of Internal Medicine, Cardiovascular and Nephro-urologic Diseases, University of Palermo, Palermo, Italy
Carlo Maria Barbagallo

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Manfredi Rizzo

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Vincenzo Pernice

³Intensive Care Unit, Villa Maria Eleonora Hospital, Palermo, Italy
Mariangela Minà

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Francesca Fayer

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Giovanni Cerasola

²Department of Internal Medicine, Cardiovascular and Nephro-urologic Diseases, University of Palermo, Palermo, Italy
Alberto Notarbartolo

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy
Maurizio Rocco Averna

¹Department of Clinical Medicine and Emerging Diseases, University of Palermo, Palermo, Italy

Abstract

Summary

In recent years new biomarkers able to measure the coronary atherosclerotic burden have been investigated. The aim of the present study was: i) to measure plasma levels of four biomarkers: C reactive protein (CRP), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin 6 (IL-6), 8-isosprostane (8-ISO),in a series of patients undergoing coronary angiography; ii) to assess the power of the biomarkers to predict critical coronary stenosis detected by angiography. The study population consisted of a group of 438 subjects undergoing coronary angiography; 160 patients with 0, 1, 2, or 3 critical vessels were selected, and biomarkers plasma levels were measured in plasma samples obtained before the procedure. The most predictive biomarker was then assayed in 120 patients with critical stenosis and 120 unmatched patients without stenosis. CRP, sICAM-1, IL-6 and 8-ISO plasma levels increased with the number of diseased vessels. All biomarkers were good predictors of critical stenosis (receiver-operator-curve [ROC] areas; CRP=0.880, IL-6=0.936, sICAM-1=0.907, 8-ISO=0.873). IL-6 was confirmed in an expanded sample of 240 subjects to be the best predictor with a ROC area=0.959.With a threshold of 3.6 ng/l,a 100% sensitivity (120/120) and a 90% specificity (108/120) was observed. In conclusion, IL-6, sICAM-1, CRP and 8-ISO are predictive of CAD. IL-6 predicts critical coronary stenosis with the highest sensitivity and specificity.

Keywords

Coronary artery disease - coronary angiography - biomarkers - interleukin 6 - C reactive protein - 8-isoprostane - sICAM-1

Full Text

References

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