Adrenoreceptors, platelet reactivity and clopidogrel resistance

Yao-Zu Xiang

doi:10.1160/TH08-09-0608

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2008; 100(05): 729-730
DOI: 10.1160/TH08-09-0608

Editorial Focus

Schattauer GmbH

Adrenoreceptors, platelet reactivity and clopidogrel resistance

Authors

Yao-Zu Xiang

¹Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, China

²Department of Haematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom

Abstract

Full Text

References

References
1 Xiang YZ, Xia Y, Gao XM. et al. Platelet activation, and antiplatelet targets and agents: current and novel strategies. Drugs 2008; 68: 1647-1664.
2 Gladding P, Webster M, Ormiston J. et al. Antiplatelet drug nonresponsiveness. Am Heart J 2008; 155: 591-599.
3 Béres BJ, Tóth-Zsámboki E, Vargová K. et al. Analysis of platelet alpha-2 adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy. Thromb Haemost 2008; 100: 829-836.
4 Aleil B, Ravanat C, Cazenave JP. et al. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005; 03: 85-92.
5 Cattaneo M. Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection. J Thromb Haemost 2007; 05: 230-237.
6 Xiang Y-Z, Kang LY, Gao XM. et al. Strategies for antiplatelet targets and agents. Thromb Res. 2008 prepub online doi:10.1016/j.thromres.2008.05.003.
7 Campbell CL, Steinhubl SR. Variability in response to aspirin: do we understand the clinical relevance?. J Thromb Haemost 2005; 03: 665-669.
8 De Miguel A, Ibanez B, Badimón JJ. Clinical implications of clopidogrel resistance. Thromb Haemost 2008; 100: 196-203.
9 von Beckerath N, von Beckerath O, Koch W. et al. P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul Fibrinolysis 2005; 16: 199-204.
10 Angiolillo DJ, Fernandez-Ortiz A, Bernardo E. et al. Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005; 116: 491-497.
11 Anfossi G, Trovati M. Role of catecholamines in platelet function pathophysiological and clinical significance. Eur J Clin Invest 1996; 26: 353-370.
12 Maayani S, Schwarz T, Craddock-Royal B. et al. Activation of the alpha(2A)-adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro. Platelets 2001; 12: 359-375.
13 Yee DL, Sun CW, Bergeron AL. et al. Aggregometry detects platelet hyperreactivity in healthy individuals. Blood 2005; 106: 2723-2729.
14 Yee DL, Bergeron AL, Sun CW. et al. Platelet hyperreactivity generalizes to multiple forms of stimulation. J Thromb Haemost 2006; 04: 2043-2050.
15 Pozgajová M, Sachs UJ, Hein L. et al. Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor. Blood 2006; 108: 510-514.
16 Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res 2006; 99: 1293-1304.
17 Nakahashi TK, Kambayashi J, Nakamura T. et al. Platelets in nonresponders to epinephrine stimulation showed reduced response to ADP. Thromb Res 2001; 104: 127-135.