On the significance of marginally low von Willebrand factor

Thromb Haemost 2008; 100(06): 1213-1214
DOI: 10.1160/TH08-09-0618

Letters to the Editor

Schattauer GmbH

Authors

Pall T. Onundarson

¹Department of Laboratory Hematology and Hemostasis Center and University of Iceland Medical School, Landspitali University Hospital, Reykjavik, Iceland
Brynja R. Gudmundsdottir

¹Department of Laboratory Hematology and Hemostasis Center and University of Iceland Medical School, Landspitali University Hospital, Reykjavik, Iceland
Victor J. Marder

²David Geffen School of Medicine at UCLA, Los Angeles, California, USA

References
1 Sadler JE. Von Willebrand disease type 1: a diagnosis in search of a disease. Blood 2003; 101: 2089-2093.
2 Eikenboom J, Van Marion V, Putter H. et al. Linkage analysis in families diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 VWD. J Thromb Haemost 2006; |p24: 774-782.
3 Tosetto A, Rodeghiero F, Castaman G. et al. A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD). J Thromb Haemost 2006; 04: 766-773.
4 Lethagen S, Hillarp A, Ekholm C. et al. Distribution of von Willebrand factor levels in young women with and without bleeding symptoms: influence of ABO blood group and promoter haplotypes. Thromb Haemost 2008; 99: 1013-1018.
5 Gudmundsdottir BR, Marder VJ, Onundarson PT. Risk of excessive bleeding associated with marginally low von Willebrand factor and mild platelet dysfunction. J Thromb Haemost 2007; 05: 274-281.
6 Onundarson PT, Gudmundsdottir BR, Arnfinnsdottir AV. et al. Von Willebrand factor does not vary during normal menstrual cycle. Thromb Haemost 2001; 85: 183-184.