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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
08 December 2008
Accepted after major revision: 01 February 2009
27 November 2017 (online)
The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
KeywordsCircular dichroism - low-molecular-weight heparin - heparinoids - principal component analysis - quality control
* Joint first authorship.
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