Thromb Haemost 2009; 102(02): 360-370
DOI: 10.1160/TH09-01-0013
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

The genetics of venous thromboembolism

A meta-analysis involving ∼120,000 cases and 180,000 controls
Reya Gohil
1  Imperial College Cerebrovascular Research Unit (ICCRU), Hammersmith Hospitals & Imperial College, London, UK
,
George Peck
1  Imperial College Cerebrovascular Research Unit (ICCRU), Hammersmith Hospitals & Imperial College, London, UK
,
Pankaj Sharma
1  Imperial College Cerebrovascular Research Unit (ICCRU), Hammersmith Hospitals & Imperial College, London, UK
› Author Affiliations
Further Information

Publication History

Received: 07 January 2009

Accepted after major revision: 14 April 2009

Publication Date:
22 November 2017 (online)

Summary

We conducted a systematic and comprehensive meta-analysis on all candidate genes to assess their genetic contribution to the aetiology of venous thromboembolism (VTE) (pulmonary embolism and deep venous thrombosis) in all ethnic groups. Electronic databases were searched until and including January 2008 for any candidate gene investigated in VTE. Odds ratios (OR) and 95% confidence intervals (CI) were determined for each gene disease association using fixed and random effect models. Our meta-analyses included ∼126,525 cases and 184,068 controls derived from 173 case-control studies, which included 21 genes (28 polymorphisms). Statistically significant associations with VTE were identified for factor V G1691A (OR 9.45; 95% CI 6.72–13.30, p<0.0001), factor V A4070G (OR 1.24; 95% CI

Footnote: PS holds a Dept. of Health (UK) Senior Fellowship.