Heparin, heparan sulfate and heparanase in inflammatory reactions

Jin-ping Li; Israel Vlodavsky

doi:10.1160/TH09-02-0091

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(05): 823-828
DOI: 10.1160/TH09-02-0091

Theme Issue Article

Schattauer GmbH

Heparin, heparan sulfate and heparanase in inflammatory reactions

Authors

Jin-ping Li

¹Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Israel Vlodavsky

²Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel

Abstract

Summary

Heparan sulfate (HS) proteoglycans at the cell surface and in the extracellular matrix of most animal tissues are essential in development and homeostasis, and are implicated in disease processes. Emerging evidence demonstrates the important roles of HS in inflammatory reactions, particularly in the regulation of leukocyte extravasation. Heparin, a classical anticoagulant, exhibits anti-inflammatory effects in animal models and in the clinic,presumably through interference with the functions of HS, as both polysaccharides share a high similarity in molecular structure. Apart of regulation during biosynthesis, the structures of HS and heparin are significantly modulated by heparanase, an endoglycosidase that is upregulated in a number of inflammatory conditions. Exploring the physiological roles of HS and heparin and the mode of heparanase action in modulating their functions during inflammation responses is of importance for future studies.

Keywords

Polysaccharide - proteoglycans - structure/function - chemokine - vascular endothelium - transmigration

Full Text

References

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