Endothelial cells in human cytomegalovirus infection: One host cell out of many or a crucial target for virus spread?

Barbara Adler; Christian Sinzger

doi:10.1160/TH09-04-0213

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2009; 102(06): 1057-1063
DOI: 10.1160/TH09-04-0213

Theme Issue Article

Schattauer GmbH

Endothelial cells in human cytomegalovirus infection: One host cell out of many or a crucial target for virus spread?

Barbara Adler

¹Max von Pettenkofer Institut für Virologie, Ludwig-Maximilians-Universität München, München, Germany

,

Christian Sinzger

²Institut für medizinische Virologie, Universität Tübingen, Tübingen, Germany

› Author Affiliations

Abstract

Summary

Endothelial cells (EC) are assumed to play a central role in the spread of human cytomegalovirus (HCMV) throughout the body. Results from in-situ analyses of infected tissues and data from cell culture systems together strongly suggest that vascular EC can support productive replication of HCMV and thus contribute to its haematogeneous dissemination. By inducing an angiogenic response, HCMV may even promote growth of its own habitat. The particular role of EC is further supported by the fact that entry of HCMV into EC is dependent on a complex of the envelope glycoproteins gH and gL with a set of proteins (UL128–131A) which is dispensable for HCMV entry into most other cell types. These molecular requirements may also be reflected by cell type-dependent differences in entry routes, i.e. endocytosis versus fusion at the plasma membrane. An animal model with trackable murine CMV is now available to clarify the pathogenetic role of EC during haematogeneous dissemination of this virus.

Keywords

Human cytomegalovirus - HCMV - endothelial cell - gH/gL complexes

Full Text

References

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