Endocytic receptor for pro-coagulant factor VIII: Relevance to inhibitor formation

Ana-Maria Navarrete; Suryasarathi Dasgupta; Maud Teyssandier; Yohann Repessé; Sandrine Delignat; Sébastien André; Jagadeesh Bayry; Srinivas V. Kaveri; Sébastien Lacroix-Desmazes

doi:10.1160/TH10-05-0294

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2010; 104(06): 1093-1098
DOI: 10.1160/TH10-05-0294

Review Article

Schattauer GmbH

Endocytic receptor for pro-coagulant factor VIII: Relevance to inhibitor formation

Ana-Maria Navarrete

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Suryasarathi Dasgupta

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Maud Teyssandier

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Yohann Repessé

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Sandrine Delignat

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Sébastien André

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Jagadeesh Bayry

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Srinivas V. Kaveri

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

,

Sébastien Lacroix-Desmazes

¹Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris, Paris, France

²Université Paris Descartes, Paris, France

³INSERM, U872, Paris, France

› Author Affiliations

Abstract

Summary

The immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.

Keywords

Haemophilia A - factor VIII - antigen-presenting cells - endocytic receptors - allo-immunisation

Full Text

References

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