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Thromb Haemost 2011; 105(02): 269-273
DOI: 10.1160/TH10-05-0307
Blood Coagulation, Fibrinolysis and Cellular Haemostasis
Schattauer GmbH

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

Ophira Salomon
1   The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
,
David M. Steinberg
2   Department of Statistics and Operations Research, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Israel
,
Michal Zucker
1   The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
,
David Varon
3   Coagulation Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
,
Ariella Zivelin
1   The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
,
Uri Seligsohn
1   The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
› Author Affiliations
Further Information

Publication History

Received: 25 May 2010

Accepted after major revision: 25 October 2010

Publication Date:
25 November 2017 (online)

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Summary

Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that patients with severe FXI deficiency have a low incidence of ischaemic stroke, but display the usual incidence of myocardial infarction. In the present study, we compared the incidence of deep-vein thrombosis (DVT) in 219 unrelated patients with severe FXI deficiency aged 20–94 to the incidence in a large population-based study. No cases of DVT were observed in the FXI-deficient cohort, a result that is significantly lower than the expected number (4.68) computed from the population-based study. The low incidence remains statistically significant when compared to three other population-based studies. These data suggest that severe FXI deficiency provides protection against DVT.

Keywords

Factor XI - factor XI deficiency - deep-vein thrombosis
 

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