Thromb Haemost 2011; 106(04): 585-590
DOI: 10.1160/TH11-03-0184
Invited Clinical Focus
Schattauer GmbH

Venous thromboembolism in Asia – an unrecognised and under-treated problem?

Pantep Angchaisuksiri
1   Division of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
› Author Affiliations
Further Information

Publication History

Received: 18 March 2011

Accepted after major revision: 29 June 2011

Publication Date:
29 November 2017 (online)


Venous thromboembolism (VTE) has been perceived for a long time to be less common in Asian populations, particularly in the Far East, than in Western populations. Generally, thromboprophylaxis is not implemented as frequently as it should be in high-risk patients. However, recent prospective studies undertaken in Asian countries have demonstrated higher rates of VTE after major surgery and in medical wards, approaching those observed in Western populations. Risk factors for VTE are not different in Asian patients from those of Western patients with the exception of thrombophilic mutations. Deficiencies of the natural anticoagulants (protein S, protein C, and antithrombin) are the predominant thrombophilias in Asia whereas factor V Leiden and prothrombin G20210A gene mutation are not found or rarely reported. Further large well-designed clinical studies are needed to evaluate the magnitude of the risk of VTE and the appropriate use of thromboprophylaxis in different clinical situations.