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Thromb Haemost 2011; 106(05): 814-819
DOI: 10.1160/TH11-05-0336
Theme Issue Article
Schattauer GmbH

Natural killer T cells in lipoprotein metabolism and atherosclerosis

Godfrey S. Getz
1   Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
,
Paul A. VanderLaan
1   Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
,
Catherine A. Reardon
1   Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands
› Author Affiliations Financial support: This work was supported by grants from the NHI Heart, Lung and Blood Institute (Grant No. HL088420) and the Foundation Leducq.
Further Information

Publication History

Received: 17 May 2011

Accepted after minor revision: 23 August 2011

Publication Date:
23 November 2017 (online)

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Summary

Cells of both the innate and adaptive immune system participate in the development of atherosclerosis, a chronic inflammatory disorder of medium and large arteries. Natural killer T (NKT) cells express surface markers characteristic of natural killer cells and conventional T cells and bridge the innate and adaptive immune systems. The development and activation of NKT cells is dependent upon CD1d, a MHC-class I-type molecule that presents lipids, especially glycolipids to the T cell receptors on NKT cells. There are two classes of NKT cells; invariant NKT cells that express a semi-invariant T cell receptor and variant NKT cells. This review summarises studies in murine models in which the effect of the activation, overexpression or deletion of NKT cells or only invariant NKT cells on atherosclerosis has been examined.

Keywords

Atherosclerosis - CD1d - NKT cells
 

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