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Thromb Haemost 2011; 106(04): 567-568
DOI: 10.1160/TH11-08-0527
Invited Editorial Focus
Schattauer GmbH

Platelet activation in the pathogenesis of obesity and vascular disease

Catherine P. M. Hayward
1   Departments of Pathology and Molecular Medicine, and Medicine, McMaster University, Hamilton, Ontario, Canada
› Author Affiliations Financial support: C.P.M.H. is supported by a Heart and Stroke Career Investigator Award.
Further Information

Publication History

Received: 18 August 2011

Accepted after minor revision: 19 August 2011

Publication Date:
29 November 2017 (online)

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  • References

  • 1 Ylä-Herttuala S, Bentzon JF, Daemen M. et al. Stabilisation of atherosclerotic plaques. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thromb Haemost 2011; 106: 1-19.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 2 Alessi MC, Juhan-Vague I. Metabolic syndrome, haemostasis and thrombosis. Thromb Haemost 2008; 99: 995-1000.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 3 Badimon L, Storey RF, Vilahur G. Update on lipids, inflammation and atherothrombosis. Thromb Haemost 2011; 105 (Suppl. 01) S34-S42.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Langer HF, Gawaz M. Platelet-vessel wall interactions in atherosclerotic disease. Thromb Haemost 2008; 99: 480-486.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Muhlestein JB. Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients. Thromb Haemost 2010; 103: 71-82.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 6 Basili S, Pacini G, Guagnano MT. et al. Insulin resistance as a determinant of platelet activation in obese women. J Am Coll Cardiol 2006; 48: 2531-2538.
    CrossrefPubMedGoogle Scholar
  • 7 Davi G, Guagnano MT, Ciabattoni G. et al. Platelet activation in obese women: role of inflammation and oxidant stress. J Am Med Assoc 2002; 288: 2008-2014.
    CrossrefPubMedGoogle Scholar
  • 8 Samocha-Bonet D, Justo D. et al. Platelet counts and platelet activation markers in obese subjects. Mediators Inflamm 2008; 2008: 834153.
    PubMedGoogle Scholar
  • 9 Kreutz RP, Alloosh M, Mansour K. et al. Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity. Diabetes Metab Syndr Obes 2011; 4: 99-105.
    PubMedGoogle Scholar
  • 10 De PG, Pannacciulli N, Coviello M. et al. sP-selectin plasma levels in obesity: association with insulin resistance and related metabolic and prothrombotic factors. Nutr Metab Cardiovasc Dis 2008; 18: 227-232.
    CrossrefPubMedGoogle Scholar
  • 11 Gallistl S, Sudi KM, Borkenstein M. et al. Correlation between cholesterol, soluble P-selectin, and D-dimer in obese children and adolescents. Blood Coagul Fibrinolysis 2000; 11: 755-760.
    CrossrefPubMedGoogle Scholar
  • 12 Missiou A, Wolf D, Platzer I. et al. CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease. Thromb Haemost 2010; 103: 788-796.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Schneider DJ, Hardison RM, Lopes N. et al. Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy. Diabetes Care 2009; 32: 944-949.
    CrossrefPubMedGoogle Scholar
  • 14 Csongrádi E, Nagy Jr B, Fulop T. et al. Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients. Thromb Haemost. 2011; 106: 683-692.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Connor DE, Exner T, Ma DD. et al. The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent pro-coagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb Haemost 2010; 103: 1044-1052.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Chen YW, Chen JK, Wang JS. Strenuous exercise promotes shear-induced thrombin generation by increasing the shedding of procoagulant microparticles from platelets. Thromb Haemost 2010; 104: 293-301.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 17 Lukasik M, Rozalski M, Luzak B. et al. Platelet activation and reactivity in the convalescent phase of ischaemic stroke. Thromb Haemost 2010; 103: 644-650.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 18 Haubold K, Rink M, Spath B. et al. Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer. Thromb Haemost 2009; 101: 1147-1155.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 19 Sinauridze EI, Kireev DA, Popenko NY. et al. Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets. Thromb Haemost 2007; 97: 425-434.
    Article in Thieme ConnectPubMedGoogle Scholar