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Thromb Haemost 2012; 107(06): 1182-1184
DOI: 10.1160/TH12-01-0012
DOI: 10.1160/TH12-01-0012
Letters to the Editor
Increased plasma levels of granzymes in adult patients with chronic immune thrombocytopenia
Authors
Financial support: This work was supported by the Swedish Research Council (K2009–65X-15424–05–3), the Swedish Federal Government under the LUA/ALF agreement, the Foundations of the National Board of Health and Welfare, Torsten and Ragnar Söderberg Foundation, Clas Groschinsky Foundation, the Arosenius Foundation, Åke Wiberg Foundation, Jeansson Foundation, Tore Nilsson Foundation for Medical Research, Magnus Bergvall Foundation and Wilhelm and Martina Lundgren Science Foundation.
Weitere Informationen
Publikationsverlauf
Received:
11. Januar 2012
Accepted after minor revision:
23. Februar 2012
Publikationsdatum:
29. November 2017 (online)
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References
- 1 Harrington WJ, Minnich V, Hollingsworth JW. et al. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med 1951; 38: 1-10.
- 2 Brighton TA, Evans S, Castaldi PA. et al. Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood 1996; 88: 194-201.
- 3 McMillan R, Wang L, Tani P. Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP). J Thromb Haemost 2003; 1: 485-491.
- 4 Warner MN, Moore JC, Warkentin TE. et al. A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura. Br J Haematol 1999; 104: 442-447.
- 5 Stockelberg D, Hou M, Jacobsson S. et al. Evidence for a light chain restriction of glycoprotein Ib/IX and IIb/IIIa reactive antibodies in chronic idiopathic thrombocytopenic purpura (ITP). Br J Haematol 1995; 90: 175-179.
- 6 Hou M, Stockelberg D, Kutti J. et al. Antibodies against platelet GPIb/IX, GPIIb/IIIa, and other platelet antigens in chronic idiopathic thrombocytopenic purpura. Eur J Haematol 1995; 55: 307-314.
- 7 Ballem PJ, Segal GM, Stratton JR. et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 1987; 80: 33-40.
- 8 McMillan R, Wang L, Tomer A. et al. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 2004; 103: 1364-1369.
- 9 Olsson B, Andersson PO, Jernas M. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 2003; 9: 1123-1124.
- 10 Chow L, Aslam R, Speck ER. et al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy. Blood 2010; 115: 1247-1253.
- 11 Darmon AJ, Nicholson DW, Bleackley RC. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B. Nature 1995; 377: 446-448.
- 12 Martinvalet D, Dykxhoorn DM, Ferrini R. et al. Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell 2008; 133: 681-692.
- 13 Fan Z, Beresford PJ, Oh DY. et al. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 2003; 112: 659-672.
- 14 Zhang D, Pasternack MS, Beresford PJ. et al. Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A. J Biol Chem 2001; 276: 3683-3690.
- 15 Zhang F, Chu X, Wang L. et al. Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura. Eur J Haematol 2006; 76: 427-431.
- 16 Zhao C, Li X, Zhang F. et al. Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies. Haematologica 2008; 93: 1428-1430.