Antithrombin levels and the risk of a first episode of venous thromboembolism. A case-control study

Matteo Nicola Dario Di Minno; Francesco Dentali; Fabrizio Veglia; Anna Russolillo; Elena Tremoli; Walter Ageno

doi:10.1160/TH12-09-0663

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 109(01): 167-169
DOI: 10.1160/TH12-09-0663

Letters to the Editor

Schattauer GmbH

Antithrombin levels and the risk of a first episode of venous thromboembolism. A case-control study

Matteo Nicola Dario Di Minno

¹Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

,

Francesco Dentali

²Department of Clinical Medicine, University of Insubria, Varese, Italy

,

Fabrizio Veglia

³IRCCS Centro Cardiologico Monzino, Milan, Italy

,

Anna Russolillo

¹Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

,

Elena Tremoli

³IRCCS Centro Cardiologico Monzino, Milan, Italy

⁴Department of Pharmacological Sciences, University of Milan, Milan, Italy

,

Walter Ageno

²Department of Clinical Medicine, University of Insubria, Varese, Italy

› Author Affiliations

Abstract

Full Text

References

References
1 De Stefano V, Finazzi G, Mannucci PM. Inherited thrombophilia: pathogenesis, clinical syndromes, and management. Blood 1996; 87: 3531-3544.
2 Lane DA, Bayston T, Olds RJ. et al. Antithrombin mutation database: 2nd (1997) update. For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 1997; 77: 197-211.
3 Simioni P, Sanson BJ, Prandoni P. et al. Incidence of venous thromboembolism in families with inherited thrombophilia. Thromb Haemost 1999; 81: 198-202.
4 Sanson BJ, Simioni P, Tormene D. et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood 1999; 94: 3702-3706.
5 De Stefano V, Leone G, Mastrangelo S. et al. Clinical manifestations and management of inherited thrombophilia: retrospective analysis and follow-up after diagnosis of 238 patients with congenital deficiency of antithrombin III, protein C, protein S. Thromb Haemost 1994; 72: 352-358.
6 Martinelli I, Mannucci PM, De Stefano V, Taioli E, Rossi V, Crosti F. et al. Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families. Blood 1998; 92: 2353-2358.
7 De Stefano V. Inherited thrombophilia and life-time risk of venous thromboembolism: is the burden reducible?. J Thromb Haemost 2004; 02: 1522-1525. DOI:10.1111/j.1538-7836.2004.00863.x.
8 Vossen CY, Conard J, Fontcuberta J. et al. Familial thrombophilia and lifetime risk of venous thrombosis. J Thromb Haemost 2004; 02: 1526-1532. DOI:10.1111/j.1538-7836.2004.00852.x.
9 Vossen CY, Conard J, Fontcuberta J. et al. Risk of a first venous thrombotic event in carriers of a familial thrombophilic defect. The European Prospective Cohort on Thrombophilia (EPCOT). J Thromb Haemost 2005; 03: 459-464. DOI:10.1111/j.1538-7836.2005.01197.x.
10 Dentali F, Gianni M. VTE recurrence in patients with inherited deficiencies of natural anticoagulants. Thromb Haemost 2009; 101: 5-6.
11 Di Minno MN, Tufano A, Guida A. et al. Abnormally high prevalence of major components of the metabolic syndrome in subjects with early-onset idiopathic venous thromboembolism. Thromb Res 2011; 127: 193-197. DOI:10.1016/j.thromres.2010.12.005.
12 Heijboer H, Brandjes DPM, Buller HR. et al. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med 1990; 323: 1512-1516. DOI:10.1056/NEJM199011293232202.
13 Bucciarelli P, Passamonti SM, Biguzzi E. et al. Low borderline plasma levels of antithrombin, protein C and protein S are risk factors for venous thromboembolism. J Thromb Haemost 2012; 10: 1783-1791. DOI:10.1111/j.1538-7836.2012.04858.x.
14 Castaldo G, Cerbone AM, Guida A. et al. Molecular analysis and genotype-phenotype correlation in patients with Antithrombin deficiency from Southern Italy. Thromb Haemost 2012; 107: 673-680. DOI:10.1160/TH11-09-0671.
15 Antón AI, Teruel R, Corral J. et al. Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels. Haematologica 2009; 94: 589-592. DOI:10.3324/haematol.2008.000604.