Association between the rs342293 polymorphism and adverse cardiac events in patients undergoing percutaneous coronary intervention

Jolanta M. Siller-Matula; Iciar Arbesu; Bernd Jilma; Gerald Maurer; Irene M. Lang; Christine Mannhalter

doi:10.1160/TH13-09-0757

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2014; 111(06): 1060-1066
DOI: 10.1160/TH13-09-0757

Platelets and Blood Cells

Schattauer GmbH

Association between the rs342293 polymorphism and adverse cardiac events in patients undergoing percutaneous coronary intervention

Jolanta M. Siller-Matula

¹Department of Cardiology, Medical University of Vienna, Austria

,

Iciar Arbesu

²Department of Laboratory Medicine, Medical University of Vienna, Austria

,

Bernd Jilma

³Department of Clinical Pharmacology, Medical University of Vienna, Austria

,

Gerald Maurer

¹Department of Cardiology, Medical University of Vienna, Austria

,

Irene M. Lang

¹Department of Cardiology, Medical University of Vienna, Austria

,

Christine Mannhalter

²Department of Laboratory Medicine, Medical University of Vienna, Austria

› Author Affiliations

Abstract

Summary

The single nucleotide polymorphism (SNP) rs342293 has been shown to influence platelet number and mean platelet volume (MPV). We investigated the association between the rs342293 polymorphism and cardiovascular outcome in a prospective cohort study. The rs342293 polymorphism was analysed in 404 patients with coronary artery disease undergoing percutaneous coronary intervention. The rates of cardiac adverse events were recorded during two years of follow-up. The polymorphism was associated with MPV (median 10.1 fL, interquartile range [IQR]: 9.6 to 10.6 in patients with the CC-allele vs 10.4 fL, IQR: 9.9 to 11.1 in G>C SNP carriers; p<0.001), but not with platelet count. Survival analysis indicated that carriers of the rs342293 G variant had a substantially higher risk to develop cardiac adverse events compared with wild type carriers during two years of follow-up (33% vs 22%; adjusted hazard ratio = 1.63, 95% confidence interval = 1.06–2.52, p=0.027). The rs342293 SNP could explain 2.9% of the variability in MPV (p=0.01). In conclusion, patients undergoing coronary stenting who carry the G-variant of the rs342293 SNP which is associated with larger MPV are at higher risk for adverse cardiovascular outcome.

Keywords

Platelet aggregation - polymorphism - genetic - outcome assessment (healthcare) - platelet count - myocardial Infarction

Full Text

References

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