Neutrophil-macrophage interplay in atherosclerosis: protease-mediated cytokine processing versus NET release

Oliver Soehnlein; Almudena Ortega-Gómez; Yvonne Döring; Christian Weber

doi:10.1160/TH15-08-0623

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2015; 114(04): 866-867
DOI: 10.1160/TH15-08-0623

Letters to the Editor

Schattauer GmbH

Neutrophil-macrophage interplay in atherosclerosis: protease-mediated cytokine processing versus NET release

Oliver Soehnlein^*

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

²DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

³Department of Pathology, Academic Medical Center (AMC), Amsterdam, the Netherlands

,

Almudena Ortega-Gómez^*

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

,

Yvonne Döring

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

²DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

,

Christian Weber

¹Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany

²DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany

› Author Affiliations

Abstract

Full Text

References

References
1 Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol 2010; 10: 427-439.
2 Megens RT, Vijayan S, Lievens D. et al. Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost 2012; 107: 597-598.
3 Quillard T, Araújo HA, Franck G. et al. TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion. Eur Heart J 2015; 36: 1394-1404.
4 Döring Y, Manthey HD, Drechsler M. et al. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation 2012; 125: 1673-1683.
5 Engelmann B. Extracellular DNA and histones as thrombus stabiliser. Thromb Haemost 2015; 113: 1164.
6 von Brühl ML, Stark K, Steinhart A. et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med 2012; 209: 819-835.
7 Knight JS, Luo W, O’Dell AA. et al. Peptidylargi-nine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circ Res 2014; 114: 947-956.
8 Warnatsch A, Ioannou M, Wang Q. et al. Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science 2015; 349: 316-320.
9 van de Veerdonk FL, Netea MG, Dinarello CA. et al. Inflammasome activation and IL-1 and IL-18 processing during infection. Trends Immunol 2011; 32: 110-116.
10 Papayannopoulos V, Metzler KD, Hakkim A. et al. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol 2010; 191: 677-691.