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Thromb Haemost 2016; 115(06): 1237-1239
DOI: 10.1160/TH16-02-0112
DOI: 10.1160/TH16-02-0112
Letters to the Editor
Cathelicidin regulates myeloid cell accumulation in adipose tissue and promotes insulin resistance during obesity
Financial support: This work was supported by the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) (Vidi project 91712303), the Academical Medical Center (AMC) Research Council, the Deutsche Forschungsgemeinschaft (DFG) (SO876/6-1, SFB914-B08, SFB1123-A05, -A06, and -B05), the Ludwig-Maximilians-University (LMU) excellent initiative, and the FöFoLe program of the LMU Medical Faculty.
Further Information
Publication History
Received:
11 February 2016
Accepted after minor revision:
24 February 2016
Publication Date:
27 November 2017 (online)
Note: The review process for this manuscript was fully handled by Gregory Y. H. Lip, Editor in Chief.
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References
- 1 Chmelar J, Chung KJ, Chavakis T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb Haemost 2013; 109: 399-406.
- 2 Elgazar-Carmon V, Rudich A, Hadad N. et al. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 2008; 49: 1894-1903.
- 3 Talukdar S, Oh da Y, Bandyopadhyay G. et al. Neutrophils mediate insulin resistance in mice fed a highfat diet through secreted elastase. Nat Med 2012; 18: 1407-1412.
- 4 Wang Q, Xie Z, Zhang W. et al. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes 2014; 63: 4172-4185.
- 5 Kahlenberg JM, Kaplan MJ. Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease. J Immunol 2013; 191: 4895-4901.
- 6 Doring Y, Drechsler M, Wantha S. et al. Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Research 2012; 110: 1052-1056.
- 7 Drechsler M, Doring Y, Megens RT. et al. Neutrophilic granulocytes - promiscuous accelerators of atherosclerosis. Thromb Haemost 2011; 106: 839-848.
- 8 De Y, Chen Q, Schmidt AP. et al. LL-37, the neutrophil granuleand epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 2000; 192: 1069-1074.
- 9 van der Does AM, Beekhuizen H, Ravensbergen B. et al. LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature. J Immunol 2010; 185: 1442-1449.
- 10 Soehnlein O, Zernecke A, Eriksson EE. et al. Neutrophil secretion products pave the way for inflammatory monocytes. Blood 2008; 112: 1461-1471.
- 11 Soehnlein O, Wantha S, Simsekyilmaz S. et al. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med 2011; 03: 103ra98.