The management of acute venous thromboembolism in clinical practice

Alexander T. Cohen; Anselm K. Gitt; Rupert Bauersachs; Eva-Maria Fronk; Petra Laeis; Patrick Mismetti; Manuel Monreal; Stefan N. Willich; Peter Bramlage; Giancarlo Agnelli; the PREFER in VTE Scientific Steering Committee and the PREFER in VTE Investigators; on behalf of

doi:10.1160/TH16-10-0793

Thrombosis and Haemostasis, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Thromb Haemost 2017; 117(07): 1326-1337
DOI: 10.1160/TH16-10-0793

Coagulation and Fibrinolysis

Schattauer GmbH

The management of acute venous thromboembolism in clinical practice

Results from the European PREFER in VTE Registry

Autoren

Alexander T. Cohen

¹Guys and St Thomas’ Hospitals NHS Foundation Trust, King’s College, London, UK
Anselm K. Gitt

²Herzzentrum Ludwigshafen Med. Klinik B, Ludwigshafen, Germany
Rupert Bauersachs

³Klinikum Darmstadt GmbH, Darmstadt, Germany

⁴Center of Thrombosis and Haemostasis, University of Mainz, Mainz, Germany
Eva-Maria Fronk

⁵Daiichi Sankyo Europe GmbH, Munich, Germany
Petra Laeis

⁵Daiichi Sankyo Europe GmbH, Munich, Germany
Patrick Mismetti

⁶CHU Saint-Etienne Hopital Nord, Saint Etienne Cedex 2, France
Manuel Monreal

⁷Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Stefan N. Willich

⁸Charité – Universitätsmedizin Berlin, Germany
Peter Bramlage

⁹Institute for Pharmacology and Preventive Medicine, Mahlow, Germany
Giancarlo Agnelli

¹⁰University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy

the PREFER in VTE Scientific Steering Committee and the PREFER in VTE Investigators

Abstract

Summary

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0% were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5%). The diagnosis was deep-vein thrombosis (DVT) in 59.5% and pulmonary embolism (PE) in 40.5%. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5%), hypertension (42.3%) and dyslipidaemia (21.1%). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2%), almost half received a vitamin K antagonist (48.7%) and nearly a quarter received a DOAC (24.5%). Almost a quarter of all presentations were for recurrent VTE, with >80% of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes.

Keywords

Venous thromboembolism - anticoagulation - registry - direct oral anticoagulants - vitamin K antagonists

Volltext

Referenzen

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