Abstract
Introduction Despite a marked recent increase in the number of publications describing the incidence
of venous thromboembolism (VTE) in Asia, and especially in mainland China, Hong Kong,
Taiwan, Korea, Japan and Singapore, there remains a lack of consensus on the true
risks, and trends over time, to inform appropriate clinical practice. The purpose
of this systematic review was therefore to examine evidence about the incidence of
symptomatic VTE in Asia.
Methods Databases were searched for studies from Asia, published between January 1995 and
February 2016, on the incidence of symptomatic VTE, deep vein thrombosis (DVT) or
pulmonary embolism. Review of eligible studies was conducted independently by two
reviewers. Data were extracted on incidence, predispositions and recurrence of VTE.
Results One thousand nighty-five studies were identified, of which 73 were eligible for full
text review and data extraction. Three population-wide estimates of VTE rates identified
from Korea, Taiwan and Hong Kong reported annual incidences of 13.8, 15.9 and 19.9
per 100,000, respectively. Nine studies of Asian hospital registries or databases
reported VTE rates ranging from 11 to 88 cases per 10,000 admissions. Population-based
estimates of post-surgical DVT rates ranged from 0.15 to 1.35%. Age was a significant
risk factor for VTE in all population groups.
Conclusion Population-wide incidence estimates in Asia were approximately 15 to 20% of the levels
recorded in western countries but have increased over time. It is anticipated this
synthesis of evidence on the incidence of VTE and its predisposing factors will increase
awareness about VTE in Asian populations.
Keywords
venous thromboembolism - deep vein thrombosis - pulmonary embolism - epidemiology
- Asian population
