Editors' Choice in the 60th Anniversary Year of Thrombosis and Haemostasis: Past, Present and Future

2017 marks a very special year for Thrombosis and Haemostasis: it marked the 60th anniversary of the journal. To commemorate this event, selected section editors were invited to create a modern portrait of the journal, reflecting the milestones of the past and encouraging a glance into future across the many topics of the journal's scope. The main directions reflected in the anniversary editorial[1] are recapitulated in this year's Editors' Choice selection of papers of high interest or citation.

We traditionally start the New Near with various position and consensus papers and current state-of-the-art developments, revealing valuable insights for researchers and clinical specialists. For instance, the role of microvesicles in the pathophysiology of thrombosis and cardiovascular disease has been intensely investigated in light of their value as potential biomarkers. We are therefore delighted to publish a relevant position paper of the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, which comprehensively summarizes the current mechanistic knowledge on the formation, composition and function of microvesicles with an endothelial, platelet, red blood cell and leukocyte origin.[2]

In addition, we also published an executive summary of a joint consensus document from the European Heart Rhythm Association and European Society of Cardiology Working Group on Thrombosis, endorsed by the ESC Working Group on Valvular Heart Disease, Cardiac Arrhythmia Society of Southern Africa (CASSA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), South African Heart (SA Heart) Association and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE), addressing the topic of antithrombotic therapy in atrial fibrillation (AF) associated with valvular heart disease.[3] This document recommends that the term ‘valvular AF’ is outdated and proposes a new functional Evaluated Heartvalves, Rheumatic or Artificial (EHRA) categorization in relation to the type of oral anticoagulant use in patients with AF, as follows: (1) EHRA Type 1 valvular heart disease which refers to AF patients with ‘valvular heart disease needing therapy with a vitamin K antagonist (VKA)’ and (2) EHRA Type 2 valvular heart disease, which refers to AF patients with ‘valvular heart disease needing therapy with a VKA or a non-VKA oral anticoagulant (NOAC)’, also taking into consideration score risk factors.

• References

• 1 Weber C, Lip GYH. Thrombosis and Haemostasis: past, present and future. Thromb Haemost 2017; 117: 1217-1218
• 2 Ridger VC, Boulanger CM, Angelillo-Scherrer A. , et al; Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Microvesicles in vascular homeostasis and diseases. Thromb Haemost 2017; 117 (07) 1296-1316
• 3 Lip GYH, Collet JP, de Caterina R. , et al. Thromb Haemost 2017; 117 (12) 2215-2236 . https://doi.org/10.1160/TH-17-10-0709
• 4 Weitz JI, Harenberg J. New developments in anticoagulants: past, present and future. Thromb Haemost 2017; 117 (07) 1283-1288
• 5 Poterucha TJ, Libby P, Goldhaber SZ. More than an anticoagulant: Do heparins have direct anti-inflammatory effects?. Thromb Haemost 2017; 117 (03) 437-444
• 6 Schulman S, Singer D, Ageno W, Casella IB, Desch M, Goldhaber SZ. NOACs for treatment of venous thromboembolism in clinical practice. Thromb Haemost 2017; 117 (07) 1317-1325
• 7 Ansell JE, Bakhru SH, Laulicht BE. , et al. Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban. Thromb Haemost 2017; 117 (02) 238-245
• 8 Albrecht D, Turakhia MP, Ries D. , et al. Pharmacokinetics of tecafarin and warfarin in patients with severe chronic kidney disease. Thromb Haemost 2017; 117 (11) 2026-2033
• 9 Albrecht D, Ellis D, Canafax DM. , et al. Pharmacokinetics and pharmacodynamics of tecarfarin, a novel vitamin K antagonist oral anticoagulant. Thromb Haemost 2017; 117 (04) 706-717
• 10 Whitlock RP, Fordyce CB, Midei MG. , et al. A randomised, double blind comparison of tecarfarin, a novel vitamin K antagonist, with warfarin. The EmbraceAC Trial. Thromb Haemost 2016; 116 (02) 241-250
• 11 Schulman S, Ageno W, Konstantinides SV. Venous thromboembolism: past, present and future. Thromb Haemost 2017; 117 (07) 1219-1229
• 12 Goldhaber SZ, Schulman S, Eriksson H. , et al. Dabigatran versus warfarin for acute venous thromboembolism in elderly or impaired renal function patients: pooled analysis of RE-COVER and RE-COVER II. Thromb Haemost 2017; 117 (11) 2045-2052
• 13 Coleman CI, Bunz TJ, Turpie AGG. Effectiveness and safety of rivaroxaban versus warfarin for treatment and prevention of recurrence of venous thromboembolism. Thromb Haemost 2017; 117 (10) 1841-1847
• 14 Trujillo-Santos J, Di Micco P, Dentali F. , et al; RIETE Investigators. Real-life treatment of venous thromboembolism with direct oral anticoagulants: the influence of recommended dosing and regimens. Thromb Haemost 2017; 117 (02) 382-389
• 15 Ageno W, Casella IB, Han CK. , et al. RE-COVERY DVT/PE: Rationale and design of a prospective observational study of acute venous thromboembolism with a focus on dabigatran etexilate. Thromb Haemost 2017; 117 (02) 415-421
• 16 Breier G, Chavakis T, Hirsch E. Angiogenesis in metabolic-vascular disease. Thromb Haemost 2017; 117 (07) 1289-1295
• 17 Ambrosino P, Tarantino L, Di Minno G. , et al. The risk of venous thromboembolism in patients with cirrhosis. A systematic review and meta-analysis. Thromb Haemost 2017; 117 (01) 139-148
• 18 Geys L, Bauters D, Roose E. , et al. ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis. Thromb Haemost 2017; 117 (01) 19-26
• 19 Wojta J. What ADAMTS13 does in the liver…. Thromb Haemost 2017; 117 (01) 6
• 20 Lallukka S, Luukkonen PK, Zhou Y. , et al. Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans. Thromb Haemost 2017; 117 (02) 286-294
• 21 Wolf D, Bukosza N, Engel D. , et al. Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO). Thromb Haemost 2017; 117 (02) 325-338
• 22 Lip G, Freedman B, De Caterina R, Potpara TS. Stroke prevention in atrial fibrillation: past, present and future. Comparing the guidelines and practical decision-making. Thromb Haemost 2017; 117 (07) 1230-1239
• 23 Esteve-Pastor MA, Rivera-Caravaca JM, Roldan V. , et al. Long-term bleeding risk prediction in ‘real world’ patients with atrial fibrillation: comparison of the HAS-BLED and ABC-Bleeding risk scores. The Murcia Atrial Fibrillation Project. Thromb Haemost 2017; 117 (10) 1848-1858
• 24 Li XS, Deitelzweig S, Keshishian A. , et al. Effectiveness and safety of apixaban versus warfarin in non-valvular atrial fibrillation patients in “real-world” clinical practice. A propensity-matched analysis of 76,940 patients. Thromb Haemost 2017; 117 (06) 1072-1082
• 25 Weber C, Badimon L, Mach F, van der Vorst EPC. Therapeutic strategies for atherosclerosis and atherothrombosis: Past, present and future. Thromb Haemost 2017; 117 (07) 1258-1264
• 26 Jamasbi J, Ayabe K, Goto S, Nieswandt B, Peter K, Siess W. Platelet receptors as therapeutic targets: past, present and future. Thromb Haemost 2017; 117 (07) 1249-1257
• 27 Winkels H, Meiler S, Smeets E. , et al. CD70 limits atherosclerosis and promotes macrophage function. Thromb Haemost 2017; 117 (01) 164-175
• 28 Santovito D, Weber C. Atherosclerosis revisited from a clinical perspective: still an inflammatory disease?. Thromb Haemost 2017; 117 (02) 231-237
• 29 Sibbing D, Angiolillo DJ, Huber K. Antithrombotic therapy for acute coronary syndrome: past, present and future. Thromb Haemost 2017; 117 (07) 1240-1248
• 30 Asher E, Frydman S, Katz M. , et al; For The PLATIS (Platelets and Thrombosis in Sheba) Study Group. Chewing versus swallowing ticagrelor to accelerate platelet inhibition in acute coronary syndrome - the CHEERS study. Thromb Haemost 2017; 117 (04) 727-733
• 31 Ten Cate H, Hackeng TM, García de Frutos P. Coagulation factor and protease pathways in thrombosis and cardiovascular disease. Thromb Haemost 2017; 117 (07) 1265-1271
• 32 Preissner KT, Herwald H. Extracellular nucleic acids in immunity and cardiovascular responses: between alert and disease. Thromb Haemost 2017; 117 (07) 1272-1282