Phlebologie 2016; 45(05): 295-303
DOI: 10.12687/phleb2335-5-2016
Review article
Schattauer GmbH

Classification of vascular malformations

Article in several languages: English | deutsch
H.-P. Berlien
1   Dept. Laser medicine, Evangelische Elisabeth-Klinik Berlin, Germany
P. Urban
1   Dept. Laser medicine, Evangelische Elisabeth-Klinik Berlin, Germany
M. Poetke
1   Dept. Laser medicine, Evangelische Elisabeth-Klinik Berlin, Germany
C. M. Philipp
1   Dept. Laser medicine, Evangelische Elisabeth-Klinik Berlin, Germany
› Author Affiliations
Further Information

Publication History

Received: 12 August 2016

Accepted: 15 August 2016

Publication Date:
22 December 2017 (online)


With the term „hemangioma” different vascular anomalies are described. Here one has to discriminate the congenital vascular tumours from the vascular anomalies. But for a clear indication a definite classification is necessary. Basis is the actual ISSVA classification. In the latest version they have incorporated the embryological aspects of the Hamburg Classification. Especially in the vasculogenetic (″extratruncular″) malformations one found increasing genetic defects. Here is an overlap to the neuro-ectodermal syndromes. By this, common therapeutic strategies are in progress.

  • References

  • 1 Al Dhaybi R, Powell J, McCuaig C, Kokta V. Differentiation of vascular tumors from vascular malformations by expression of Wilms tumor 1 gene: evaluation of 126 cases. J Am Acad Dermatol 2010; 63: 1052-1057.
  • 2 Berlien H-P. Laser Treatment in Vascular Malformations. In Mattassi R, Loose DA, Vaghi M. Eds Hemangiomas and Vascular Malformations- An Atlas of Diagnosis and Treatment. 2nd ed. Springer Milan-Berlin Heidelberg: 2015: 291-305.
  • 3 Berlien H-P. Laser Therapy for Venous Malformations. In Head and Neck Vascular Anomalies A Practical Case-Based Approach. Richter GT, James Y. San Diego: Suen Plural Publishing; 2015: 224-228.
  • 4 Berlien H-P, Poetke M, Philipp C. Phakomatosen. In Oldhafer M. ed Transitionsmedizin. Stuttgart: Schattauer Stuttgart; 2015: 169-180.
  • 5 Berlien H-P. et al. Clinical Features and Evaluation of Superficial & Deep Capillary malformation. In Congenital Vascular Malformations- A Comprehensive Review of Current Management. Kim Y-W, Lee B-B, Yakes WF, Do Y-S. Eds Berlin: Springer; 2017. Kap. 19..
  • 6 Hulmani M, Kudur M. Misnomers in dermatology: Time to change and update. IJDVL 2013; 79 (04) 479-491.
  • 7 Lawley LP. et al. Expression of Wilms Tumor 1 Gene Distinguishes Vascular Malformations From Proliferative Endothelial Lesions. Arch Dermatol 2005; 141: 1297-1300.
  • 8 Lee BB, Baumgartner I, Berlien H-P. et al. Current concepts on the management of arterio-venous malformations Consensus Document of the International Union Angiology (IUA) – 2013. Intl Angiol 2013; 32: 9-36.
  • 9 Lee BB, Baumgartner I, Berlien H-P. et al. Diagnosis and Treatment of Venous Malformations. Consensus Document of the International Union of Phlebology (IUP): updated 2013. Int Angiol 2015; 34 (02) 97-149.
  • 10 Mesquita deNettoI AC. et al. Wilms tumor 1 protein is not expressed in oral lymphangiomas. Braz Dent J. 2012 23..
  • 11 Philipp CM, Almohamad A, Adam M. et al. Pyogenic granuloma – Nd:YAG laser treatment in 450 patients Granuloma pyogenicum. Photonics & Lasers in Medicine 2015; 215-226.
  • 12 Philipp CM, Poetke M, Berlien H-P. Vascular tumors and malformations of the pelvic and genital region – Classification and laser treatment. Medical Laser Application 2009; 24: 27-51.
  • 13 Poetke M, Philipp C, Berlien H-P. Vaskuläre Malformationen. Phlebologischer Bildatlas. In: Rabe E, Stücker M. (Hrsg) Köln: Viavital; 2015: 114-123.
  • 14 Requena L, Sangueza OP. Cutaneous vascular anomalies. Part I. Hamartomas, malformations, and dilation of preexisting vessels. J Am Acad Dermatol 1997; 37: 523-549.
  • 15 Urban P, Berlien H-P, Tinschert S. Vascular Malformations in Particular Syndromes with Regional Overgrowth European. Journal of Vascular Medicine 2013; 42: 35-26.
  • 16 Wassef M. et al. on behalf of the ISSVA Board and Scientific Committee. Vascular Anomalies Classification: Recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics 2015; 136 (01) 2014-3673.
  • 17 Yang L, Han Y, Saurez FSaiz, Minden MD. A tumor suppressor and oncogene: the WT1 story. Leukemia 2007; 21: 868-876.