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Tierarztl Prax Ausg G Grosstiere Nutztiere 2017; 45(06): 350-356
DOI: 10.15653/TPG-170079
Originalartikel
Schattauer GmbH

Interstitial nephritis in pigs

Article in several languages: deutsch | English
Ines Spiekermeier
1   Landwirtschaftskammer Niedersachsen, Oldenburg
,
Mechthild Freitag
2   Fachbereich Agrarwissenschaften, Fachhochschule Südwestfalen
,
Wolfgang Baumgärtner
3   Institut für Pathologie, Tierärztliche Hochschule Hannover
› Author Affiliations
Further Information

Publication History

Eingegangen: 05 February 2017

Akzeptiert nach Revision: 29 June 2017

Publication Date:
09 January 2018 (online)

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Summary

Objective: Interstitial nephritis as a form of renal diseases can be found frequently among pigs. Nevertheless, prevalence and aetiology need to be investigated in more detail as reports about detailed analysis are lacking. Material and methods: In the present study, a total of 169 kidneys of conventionally and organically raised pigs were randomly chosen at slaughter and classified according to the degree of inflammation and the participating inflammatory cells. Moreover, PCV2 as an infectious agent was analysed by immunohistochemistry and in-situ hybridisation. Results: All of the investigated kidneys displayed mild interstitial lesions. Inflammatory cells included lymphocytes, macrophages, plasma cells, eosinophilic and neutrophilic granulocytes. Significant (p ≤ 0.0001) differences concerning the grade of inflammation and inflammatory cell occurrence could be observed between kidneys of conventionally and organically raised pigs. In comparison to conventionally raised pigs organically raised pigs showed significant (p ≤ 0.0001) more frequently a mild form of nephritis as well as a significant (p ≤ 0.0001) more frequent occurrence of lympho cytes and macrophages. In contrast to that, conventionally raised pigs had a significant (p ≤ 0.0001) higher occurrence rate of a mild to moderate form of nephritis as well as a significant (p ≤ 0.0001) higher level in occurrence of lymphocytes, macrophages, plasma cells, and neutrophilic granulocytes when compared to organically raised pigs. PCV2 DNA was detected in the kidney of only one animal. Conclusion: Interstitial nephritis was found in conventionally and organically raised pigs and PCV2 was ruled out as a major pathogen for interstitial nephritis in slaughter pigs. Clinical relevance: Because of the high prevalence and unknown cause further investigations are necessary to delineate the clinic relevance of this alteration and its pathogenesis.

Keywords

Renal diseases - porcine circovirus type 2 - organic husbandry system - conventional husbandry system
 

  • Literatur

  • 1 Allan GM, Ellis JA. Porcine circoviruses: a review. J Vet Diagn Invest 2000; 12 (01) 3-14.
    CrossrefPubMedGoogle Scholar
  • 2 Baker TF, McEwen SA, Prescott JF, Meek AH. The prevalence of leptospirosis and its association with multifocal interstitial nephritis in swine at slaughter. Can J Vet Res 1989; 3 (03) 290-294.
    PubMedGoogle Scholar
  • 3 Büngener W, Mehlitz D. Histopathological findings in mini-pigs infected with different strains of Trypanosoma brucei . Tropenmed Parasitol 1984; 35 (02) 109-114.
    PubMedGoogle Scholar
  • 4 Boqvist S, Montgomery JM, Hurst M, Thu HT, Engvall EO, Gunnarsson A, Magnusson U. Leptospira in slaughtered fattening pigs in southern Vietnam: presence of the bacteria in the kidneys and association with morphological findings. Vet Microbiol 2003; 93 (04) 361-368.
    CrossrefPubMedGoogle Scholar
  • 5 Calsamiglia M, Segales J, Quintana J, Rossel C, Domingo M. Detection of porcine circovirus type 1 and 2 in serum and tissue samples of pigs with and without postweaning multisystemic wasting syndrome. J Clin Microbiol 2002; 40 (05) 1848-1850.
    CrossrefPubMedGoogle Scholar
  • 6 Carpenter JA, Scorgie A, Josephson G. Leptospira interrogans serovar Pomona infection associated with carcass condemnation of swine at slaughter. J Swine Health Prod 2006; 14 (03) 145-148.
    PubMedGoogle Scholar
  • 7 Caspari K, Grimm F, Kühn N, Caspari NC, Basso W. First report of naturally acquired clinical sarcocystosis in a pig breeding stock. Vet Parasitol 2011; 177 (1–2): 175-178.
    CrossrefPubMedGoogle Scholar
  • 8 Cooper VL, Hesse RA, Doster AR. Renal lesions associated with experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection. J Vet Diagn Invest 1997; 9 (02) 198-201.
    CrossrefPubMedGoogle Scholar
  • 9 De Vries V. Erhebung von Organbefunden und Konfiskatabzügen von Schlachtschweinen an Schlachthöfen in der Schweiz und deren Korrelation mit Betriebs- und Managementdaten. University of Zurich; 2010. Available from: http://www.zora.uzh.ch/42567/1/Erhebung1.pdf
    Google Scholar
  • 10 Drolet R, D’Allaire S, Larochelle R, Magar R, Ribotta M, Higgins R. Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter. Vet Rec 2002; 150 (05) 139-143.
    CrossrefPubMedGoogle Scholar
  • 11 Filho JXO, de Paula DAJ, Morés N, Pescador CA, Ciacci-Zanella JR, Coldebella A, Dutra V, Nakazato L. Interstitial nephritis of slaughtered pigs in the State of Mato. Braz J Vet Med 2012; 32 (04) 313-318.
    PubMedGoogle Scholar
  • 12 González J, Puschner B, Pérez V, Ferreras MC, Delgado L, Muñoz M, Pérez C, Reyes LE, Velasco J, Fernández V, García-Marín JF. Nephrotoxicosis in Iberian piglets subsequent to exposure to melamine and derivatives in Spain between 2003 and 2006. J Vet Diagn Invest 2009; 21 (04) 558-563.
    CrossrefPubMedGoogle Scholar
  • 13 Jacobsen B, Krueger L, Seeliger F, Bruegmann M, Segalés J, Baumgaertner W. Retrospective study on the occurrence of porcine circovirus 2 infection and associated entities in Northern Germany. Vet Microbiol 2009; 138 (1–2): 27-33.
    CrossrefPubMedGoogle Scholar
  • 14 Jansen JH, Nordstoga K. Renal lesions in Norwegian slaughter pigs. Macroscopic and light microscopic studies. Zentralbl Veterinarmed A 1992; 39 (08) 582-592.
    CrossrefPubMedGoogle Scholar
  • 15 Joo HS, Donaldson-Wood CR, Johnson RH, Campbell RS. Pathogenesis of porcine parvovirus infection: pathology and immunofluorescene in the foetus. J Comp Pathol 1977; 87 (03) 383-391.
    CrossrefPubMedGoogle Scholar
  • 16 Kekarainen T, Sibila M, Segalés J. Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain. J Gen Virol 2006; 87 (04) 833-837.
    CrossrefPubMedGoogle Scholar
  • 17 Larsen NB, Tondering E. Leucocytic interstitial nephritis in pigs. Nord Vet Med 1954; 6: 35-46.
    PubMedGoogle Scholar
  • 18 Lee CH, Ooi PT, Sheikh Omar AR, Lim BK. Melamine toxicity in pigs. Pertanika J Trop Agric Sci 2011; 34 (01) 175-179.
    PubMedGoogle Scholar
  • 19 Li M, Anderson GD, Phillips BR, Kong W, Shen DD, Wang J. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos 2006; 34 (04) 547-555.
    CrossrefPubMedGoogle Scholar
  • 20 López A, Chiers K, Van Hoorebeke S, Stuyven E, Meyns T, Nauwynck H, Welle M, Maes D. Porcine ulcerative dermatitis syndrome in sows: a form of vesicular cutaneous lupus erythematosus?. Vet Rec 2009; 165 (17) 501-506.
    CrossrefPubMedGoogle Scholar
  • 21 Martínez J, Segalés J, Aduriz G, Atxaerandio R, Jaro P, Ortega J, Peris B, Corpa JM. Pathological and aetiological studies of multifocal interstitial nephritis in wasted pigs at slaughter. Res Vet Sci 2006; 81 (01) 92-98.
    CrossrefPubMedGoogle Scholar
  • 22 Maxie MG, Newman SJ. Urinary System. In: Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 5th ed.. Maxie MG. ed. St. Louis: Mosby Elsevier; 2007: 425-522.
    Google Scholar
  • 23 Newman SJ, Confer AW, Panciera RJ. Urinary System. In: Pathologic Basis of Veterinary Disease. 4th ed. McGavin MD, Zachary JF. eds. St. Louis: Mosby Elsevier; 2007: 613-692.
    Google Scholar
  • 24 Nietfeld JC, Leslie-Steen P. Interstitial nephritis in pigs with adenovirus infection. J Vet Diagn Invest 1993; 5 (02) 269-273.
    CrossrefPubMedGoogle Scholar
  • 25 Opriessnig T, Langohr I. Current state of knowledge on porcine circovirus type 2-associated lesions. Vet Pathol 2013; 50 (01) 23-38.
    CrossrefPubMedGoogle Scholar
  • 26 Radaelli E, Del Piero F, Aresu L, Sciarrone F, Vicari N, Mattiello S, Tagliabue S, Fabbi M, Scanziani E. Expression of major histocompatibility complex class II antigens in porcine leptospiral nephritis. Vet Pathol 2009; 46 (05) 800-809.
    CrossrefPubMedGoogle Scholar
  • 27 Rosell C, Segalés J, Plana-Durán J, Balasch M, Rodríguez-Arrioja GM, Kennedy S, Allan GM, McNeilly F, Latimer KS, Domingo M. Hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. J Comp Pathol 1999; 120: 59-78.
    CrossrefPubMedGoogle Scholar
  • 28 Sarli G, Mandrioli L, Panarese S, Brunetti B, Segalés J, Domínquez J, Marcato PS. Characterization of interstitial nephritis in pigs with naturally occurring postweaning multisystemic wasting syndrome. Vet Pathol 2008; 45 (01) 12-18.
    CrossrefPubMedGoogle Scholar
  • 29 Scanziani E, Sironi G, Mandelli G. Immunoperoxidase studies on leptospiral nephritis of swine. Vet Pathol 1989; 26 (05) 442-444.
    CrossrefPubMedGoogle Scholar
  • 30 Seeliger FA, Brügmann ML, Krüger L, Greiser-Wilke I, Verspohl J, Segalés J, Baumgärtner W. Porcine circovirus type 2-associated cerebellar vasculitis in postweaning multisystemic wasting syndrome (PMWS)-affected pigs. Vet Pathol 2007; 44 (05) 621-634.
    CrossrefPubMedGoogle Scholar
  • 31 Sheik-Omar AR, Kadir AR, Bahaman AR. A study on the pathology of swine kidneys condemned at slaughter at an abattoir in Malaysia. Proceedings of the 3rd AAAP Animal Sci Congress. May 6–10 1985; 1: 516-518.
    PubMedGoogle Scholar
  • 32 Taverne FJ, Van Geijlswijk Heederik DJ, Wagenaar JA, Mouton JW. Modelling concentrations of antimicrobial drugs: comparative pharmacokinetics of cephalosporin antimicrobials and accuracy of allometric scaling in foodproducing and companion animals. BMC Vet Res 2016; 12 (01) 185.
    CrossrefPubMedGoogle Scholar
  • 33 Vezzali E, Manno RA, Salerno D, Oberto G, Nyska A, Ramot Y. Spontaneous glomerulonephritis in Göttingen minipigs. Toxicol Pathol 2011; 39 (04) 700-705.
    CrossrefPubMedGoogle Scholar
  • 34 Weiss E. Harnorgane. In: Grundriss der speziellen pathologischen Anatomie der Haustiere. 6. Aufl.. Dahme E, Weiss E. Hrsg. Stuttgart: Enke; 2007: 173-201.
    Google Scholar
  • 35 Zwald AG, Ruegg PL, Kaneene JB, Warnick LD, Wells SJ, Fossler C, Halbert LW. Management practices and reported antimicrobial usage on conventional and organic dairy farms. J Dairy Sci 2004; 87 (01) 191-202.
    CrossrefPubMedGoogle Scholar