PDF herunterladen
CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2021; 79(02): 133-138
DOI: 10.1590/0004-282X-ANP-2020-0209
Article

Older adults with epilepsy: memory complaints and objective neuropsychological performance

Idosos com epilepsia: queixa de memória e desempenho neuropsicológico objetivo
Glória Maria Almeida Souza Tedrus 
1   Pontifícia Universidade Católica de Campinas, Programa de Pós-Graduação em Ciências da Saúde, Campinas SP, Brazil.
,
Lorena Murta dos Santos 
2   Pontifícia Universidade Católica de Campinas, Faculdade de Medicina, Campinas SP, Brazil.
,
Fernanda Meneghetti 
2   Pontifícia Universidade Católica de Campinas, Faculdade de Medicina, Campinas SP, Brazil.
› Institutsangaben
› Weitere Informationen
   Lizenzen und Reprints

ABSTRACT

Introduction: People with epilepsy frequently complain of poor memory. Objective: To assess the occurrence of memory complaints in older adults with epilepsy (OAE) and whether it is associated with clinical variables, objective cognitive performance, and quality of life (QoL). Methods: The Memory Complaint Questionnaire (MAC-Q) was related to objective cognitive performance, the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), the Quality of Life in Epilepsy Inventory (QOLIE-31), and the clinical characteristics of 83 OAE. Results: OAE showed worse cognitive performance and higher MAC-Q scores when compared to a similar control group (n=40). Impairment in multiple cognitive domains occurred in 34 (41%) OAE and was associated with older age and lower educational level. Memory complaints (MAC-Q≥25) were reported by 45 (54.2%) OAE and associated with older age, lower educational level, onset at ≥60 years, higher NDDI-E scores, lower QOLIE-31 scores, and impairment in multiple cognitive domains. Conclusions: OAE presented worse cognitive performance and greater memory complaints. Episode onset at ≥60 years of age was associated with complaints, but not with objective cognitive deficit. We found an association between subjective and objective cognitive performance, with aspects of epilepsy and worse QoL scores.

RESUMO

Introdução: A queixa de memória fraca é frequente em pessoas com epilepsia. Objetivo: Avaliar a ocorrência de queixas de memória em idosos com epilepsia (IE) e se há associação com variáveis clínicas, desempenho cognitivo objetivo e qualidade de vida (QV). Métodos: O questionário de queixa de memória (memory complaint questionnaire — MAC-Q) foi relacionado ao desempenho cognitivo objetivo, o inventário de depressão de transtornos neurológicos para epilepsia (neurological disorders depression inventory for epilepsy — NDDI-E), o QOLIE-31 e com as características clínicas de 83 IE. Resultados: Houve desempenho cognitivo inferior e maiores escores no MAC-Q em IE quando comparados aos de um grupo controle similar (n=40). Comprometimento de múltiplos domínios cognitivos ocorreu em 34 (41%) IE e associou-se a maior idade e menor escolaridade. Queixas de memória (MAC-Q≥25) foram observadas em 45 (54,2%) IE e associadas a idade mais elevada, menor escolaridade, início das crises aos ≥60 anos, maiores escores no NDDI-E, menores escores no QOLIE-31 e comprometimento de múltiplos domínios cognitivos. Conclusões: Pior desempenho cognitivo e maiores queixa de memória ocorreram em IE. Crises com início aos ≥60 anos foram associadas a queixas, mas não a déficit objetivo cognitivo. Houve associação entre desempenho cognitivo subjetivo e objetivo, com aspectos da epilepsia e pior QV.

Keywords:

Epilepsy - Memory - Aged

Palavras-chave:

Epilepsia - Memoria - Idoso

Authors’ contribution:

all authors contributed in writing and editing the main manuscript. GMAST contributed to the conceptualization and formal analysis.




Publikationsverlauf

Eingereicht: 12. Mai 2020

Angenommen: 06. Juli 2020

Artikel online veröffentlicht:
04. Juli 2023

© 2021. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil

 

  • References

  • 1 Mattos P, Lino V, Rizo L, Alfano A, Araujo C, Raggio R. Memory complains and test performance in healthy elderly persons. Arq Neuro-Psiquiatr. 2003 Dec;61(4):920-4. https://doi.org/10.1590/S0004-282X2003000600006
  • 2 Jonker C, Geerlings MI, Schmand B. Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychiatry. 2000 Nov;15(11):983-91. https://doi.org/10.1002/1099-1166(200011)15:11<983::aid-gps238>3.0.co;2-5
  • 3 Fisher RS, Vickrey BG, Gibson P, Hermann B, Penocich P, Scherer A, et al. The impact of epilepsy from the patient's perspective I. Descriptions and subjective perceptions. Epilepsy Res. 2000 Aug;41(1):39-51. https://doi.org/10.1016/s0920-1211(00)00126-1
  • 4 Berg AT. Epilepsy, cognition, and behavior: The clinical picture. Epilepsia. 2011 Jan;52(Suppl 1):7-12. https://doi.org/10.1111/j.1528-1167.2010.02905.x
  • 5 Elger CE, Helmstaedter C, Kurthen M. Chronic epilepsy and cognition. Lancet Neurol. 2004 Nov;3(11):663-72. https://doi.org/10.1016/S1474-4422(04)00906-8
  • 6 Salas-Puig J, Gil-Nagel A, Serratosa JM, Sanchez-Alvarez JC, Elices E, Villanueva V, et al. Self-reported memory problems in everyday activities in patients with epilepsy treated with antiepileptic drugs. Epilepsy Behav. 2009 Apr;14(4):622-7. https://doi.org/10.1016/j.yebeh.2009.01.015
  • 7 Marino SE, Meador KJ, Loring DW, Okun MS, Fernandez HH, Fessler AJ, et al. Subjective perception of cognition is related to mood and not to performance. Epilepsy Behav. 2009 Mar;14(3):459-64. https://doi.org/10.1016/j.yebeh.2008.12.007
  • 8 Vermeulen J, Aldenkamp AP, Alpherts WCJ. Memory complaints in epilepsy: correlations with cognitive performance and neuroticism. Epilepsy Res. 1993 Jun;15(2):157-70. https://doi.org/10.1016/0920-1211(93)90096-p
  • 9 Hendriks MPH, Aldenkamp AP, van der Vlugt H, Alpherts WCJ, Vermeulen J. Memory complaints in medically refractory epilepsy: relationship to epilepsy-related factors. Epilepsy Behav. 2002 Apr;3(2):165-72. https://doi.org/10.1006/ebeh.2002.0320
  • 10 Galioto R, Blum AS, Tremont G. Subjective cognitive complains versus objective neuropsychological performance in older adult with epilepsy. Epilepsy Behav. 2015 Oct;51:48-52. https://doi.org/10.1016/j.yebeh.2015.06.035
  • 11 Martin R, Griffith HR, Faught E, Gilliam F Mackey M, Vogtle L. Cognitive functioning in community dwelling older adults with chronic partial epilepsy. Epilepsia. 2005 Feb;46(2):298-303. https://doi.org/10.1111/j.0013-9580.2005.02104.x
  • 12 Elixhauser A, Leidy NK, Meador K, Means E, Willian MK. The relationship between memory performance, perceived cognitive function, and mood in patients with epilepsy. Epilepsy Res. 1999 Oct;37(1):13-24. https://doi.org/10.1016/s0920-1211(99)00036-4
  • 13 Au A, Leung P, Kwok A, Li P, Lui C, Chan J. Subjective memory and mood of Hong Kong Chinese adults with epilepsy. Epilepsy Behav. 2006 Aug;9(1):68-72. https://doi.org/10.1016/j.yebeh.2006.04.004
  • 14 Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 Apr;58(4):512-21. https://doi.org/10.1111/epi.13709
  • 15 Crook TH, Feher EP, Larrabee GJ. Assessment of memory complaint in age-associated memory impairment: the MAC-Q. Int Psychogeriatr. Fall 1992;4(2):165-76. https://doi.org/10.1017/s1041610292000991
  • 16 Folstein MF, Folstein SE, Mchugyh PR. “Mini-Mental State”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. https://doi.org/10.1016/0022-3956(75)90026-6
  • 17 Brucki SM, Nitrini R, Caramelli P, Bertolucci PH, Okamoto IH. Suggestions for utilization of the mini-mental state examination in Brazil. Arq Neuro-Psiquiatr. 2003 Sep;61(3B):777-81. https://doi.org/10.1590/s0004-282x2003000500014
  • 18 Nitrini R, Caramelli P, Herrera Jr E, Porto CS, Charchat-Fichman H, Carthery MT, et al. Performance of illiterate and literate nondemental elderly subjects in two testes of long-term memory. J. Int. Neuropsychol. Soc. 2004 Jul;10(4):634-8. https://doi.org/10.1017/S1355617704104062
  • 19 Sunderland T, Hill JL, Mellow AM, Lawlor B, Gundersheime J, Newhouse P, et al. Clock drawing in Alzheimer's disease: a novel measure of dementia severity. J Am Geriatr Soc. 1989 Aug;37(8):725-9. https://doi.org/10.1111/j.1532-5415.1989.tb02233.x
  • 20 Brucki SMD, Rocha MSG. Category fluency test: effects of age, gender and education on total scores, clustering switching in Brazilian Portuguese-speaking subjects. Braz J Med Biol Res. 2004 Dec;37(12):1771-7. https://doi.org/10.1590/S0100-879X2004001200002
  • 21 Gilliam FG, Barry JJ, Hermann BP, Meador KJ, Vahle V, Kanner AM. Rapid detection of major depression in epilepsy: a multicentre study. Lancet Neurol. 2006 May;5(5):399-405. https://doi.org/10.1016/S1474-4422(06)70415-X
  • 22 Cramer JA, Perrine K, Devinky O, Bryant-Comstock L, Meador K, Hermann B. Development and cross-cultural translations of a 32-item quality of life in epilepsy inventory. Epilepsia. 1998 Jan;39(1):81-8. https://doi.org/10.1111/j.1528-1157.1998.tb01278.x
  • 23 Giovagnolli AR, Mascheroni S, Avanzini G. Self-reporting of everyday memory in patients with epilepsy; relation to neuropsychological, clinical, pathological and treatment factors. Epilepsy Res. 1997 Sep;28(2):119-28. https://doi.org/10.1016/s0920-1211(97)00036-3
  • 24 Grewe P, Nikstat A, Koch O, Koch-Stoecker S, Bien CG. Subjective memory complains in patients with epilepsy: The role of depression, psychological distress, and attentional functions. Epilepsy Res. 2016 Nov;127:78-86. https://doi.org/10.1016/j.eplepsyres.2016.08.022
  • 25 Rayner G, Wrench JM, Wilson SJ. Differential contribution of objective memory and mood to subjective memory complaints in refractory focal epilepsy. Epilepsy Behav. 2010 Nov;19(3):359-64. https://doi.org/10.1016/j.yebeh.2010.07.019
  • 26 Feldman L, Lapin B, Busch RM, Bautista JF. Evaluating subjective cognitive impairment in the adult epilepsy clinic: effects of depression, number of antiepileptic medications, and seizure frequency. Epilepsy Behav. 2018 Apr;81:18-24. https://doi.org/10.1016/j.yebeh.2017.10.011
  • 27 Baños JH, LaGory J, Sawrie S, Faught E, Knowlton R, Prasad A, et al. Self-report of cognitive abilities in temporal lobe epilepsy: cognitive, psychosocial, and emotional factors. Epilepsy Behav. 2004 Aug;5(4):575-9. https://doi.org/10.1016/j.yebeh.2004.04.010
  • 28 Suurmeijer T, Reuvecamp M, Aldenkamp B. Social functioning, psychological functioning, and quality of life in epilepsy. Epilepsia. 2001 Sep;42(9):1160-8. https://doi.org/10.1046/j.1528-1157.2001.37000.x