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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2021; 79(12): 1090-1094
DOI: 10.1590/0004-282X-ANP-2020-0543
Articles

Association between baseline Mini-Mental State Examination score and dementia incidence in a cohort of oldest old

Associação entre a pontuação inicial do Miniexame do Estado Mental e a incidência de demência em uma coorte de longevos
Débora Yumi HAYASHIDA 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Geriatria e Gerontologia, São Paulo SP, Brazil.
,
Alessandro Ferrari JACINTO 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Geriatria e Gerontologia, São Paulo SP, Brazil.
,
Lara Miguel Quirino ARAÚJO 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Geriatria e Gerontologia, São Paulo SP, Brazil.
,
Clineu de Mello ALMADA  FILHO
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Geriatria e Gerontologia, São Paulo SP, Brazil.
,
Ana Beatriz DI TOMMASO 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Geriatria e Gerontologia, São Paulo SP, Brazil.
,
Maysa Seabra CENDOROGLO 
1   Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Geriatria e Gerontologia, São Paulo SP, Brazil.
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ABSTRACT

Background: The Brazilian population has aged rapidly. The oldest old, defined as persons aged 80 years or older, is the fastest growing segment of the Brazilian population. Several instruments have been used to assess the cognitive performance of the older people and predict dementia. One of the most commonly used is the Mini-Mental State Examination (MMSE). Objective: The aim of this study was to investigate the relationship between baseline MMSE score and the incidence of dementia in a Brazilian cohort of independent oldest old. Methods: Sociodemographic data and serial cognitive assessment of 248 older adults were analyzed. Results: Mean follow-up time of subjects was 4.0(±1.9) years, 71.4% were women, and mean MMSE score at entry was 25(±3.5). Mean MMSE scores at baseline were significantly higher (p=0.001) in the cognitively intact group than in those who developed dementia. The logistic regression showed that for a one point increase in MMSE score at baseline there was a 10% reduction in the probability of dementia. Conclusions: In the Brazilian scenario of a rapidly growing population of oldest old, the extensive use of the MMSE gives rise to the need not only to determine its effectiveness for screening dementia, but also to interpret its score in terms of future conversion to dementia.

RESUMO

Antecedentes: A população brasileira envelheceu rapidamente. Os longevos, definidos como pessoas com 80 anos ou mais, são o segmento da população brasileira que mais cresce. Diversos instrumentos têm sido usados para avaliar o desempenho cognitivo de idosos e para predizer demência. Um dos instrumentos mais utilizados é o Miniexame do Estado Mental (MEEM). Objetivo: Nosso objetivo foi investigar a relação entre a pontuação inicial do MEEM e a incidência de demência em uma coorte brasileira de idosos longevos independentes. Métodos: Foram avaliados dados de 248 idosos por meio de um questionário sociodemográfico e de avaliações cognitivas seriadas. Resultados: O tempo médio de acompanhamento dos participantes foi de 4,0 (±1,9) anos. Eram mulheres 71,4% deles e a pontuação média do MEEM na entrada foi de 25 (±3,5) pontos. As pontuações médias do MEEM no início do estudo foram significativamente maiores (p=0,001) no grupo cognitivamente intacto do que naqueles que desenvolveram demência. A regressão logística mostrou que, para cada ponto a mais na pontuação do MEEM no início do estudo, houve redução de 10% na probabilidade de desenvolver demência. Conclusões: No cenário brasileiro de rápido crescimento da população de idosos longevos, o uso da ferramenta cognitiva mais amplamente utilizada cria a necessidade de determinar não apenas sua eficácia no rastreamento da demência, mas também de interpretar seu escore considerando-se a futura conversão para demência.

Keywords:

Dementia - Incidence - Aged - 80 and over

Palavras-chave:

Demência - Incidência - Idoso de 80 Anos ou mais

Authors’ contribution:

DYH: designed the study, collected and analyzed data; AFJ: analyzed data and wrote the paper; LMQA: revised the paper; CMAF: revised the paper; ABT: collected data and revised the paper; MSC: designed the study, analyzed data and revised the paper.


Support:

This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (2011/12753-8) (2014/04398-1).




Publication History

Received: 29 November 2020

Accepted: 15 February 2021

Article published online:
07 June 2023

© 2021. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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