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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(09): 582-587
DOI: 10.1590/0004-282X20180085
Article

Chronic migraine patients show cognitive impairment in an extended neuropsychological assessment

Pacientes com migrânea crçnica apresentam déficits cognitivos em uma avaliação neuropsicológica estendida
Karen S. Ferreira
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Caroliny T. Teixeira
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Carolina Cáfaro
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Gabriela Z. Oliver
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Gabriela L. P. Carvalho
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Larissa A. S. D. Carvalho
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Brenda G. Silva
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Fernanda B. B. Haes
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
,
Marcelo C. Ciciarelli
1   Centro Universitário Barão de Mauá, Faculdade de Medicina, Neurologia Clínica, Ribeirão Preto SP, Brasil
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ABSTRACT

The objective of the present study was to assess the presence of cognitive deficits in patients with chronic migraine, and to assess the main factors that trigger cognitive disorders, such as comorbidities or the use of medications.

Methods: Chronic migraine and control groups were interviewed in a case-control study. The frequency and intensity of the headache, medication used and associated comorbidities were determined. All patients were submitted to an extended neuropsychological assessment.

Results: The chronic migraine group (n = 30) had a worse performance in the Montreal Cognitive Assessment Test (p = 0.00), Verbal Fluency (p = 0.00), Stroop (p = 0.00), Clock Drawing Test (p = 0.00), Digit Span (p = 0.00) and Matrix Reasoning (p = 0.01). After statistical adjustment by linear regression, migraine continued to be the only relevant factor in the poorer performance in the Montreal Cognitive Assessment, Verbal Fluency, Clock Drawing and Stroop tests.

Conclusion: Patients with chronic migraine have cognitive deficits in multiple tasks, regardless of the presence of comorbidities or the use of medications.

RESUMO

O objetivo do presente estudo foi avaliar a presença de déficits cognitivos em pacientes com migrânea crçnica e avaliar os principais fatores que desencadeiam transtornos cognitivos, como comorbidades e uso de medicações.

Métodos: Pacientes com migrânea crçnica (n = 30) e controles foram entrevistados, em um estudo caso-controle. A frequência e intensidade da cefaleia, medicações utilizadas e comorbidades associadas foram determinadas. Todos os pacientes foram submetidos a uma avaliação neuropsicológica estendida.

Resultados: Os pacientes com migrânea crçnica apresentaram uma pior performance no Montreal Cognitive Assessment (p = 0.00), Fluência Verbal (p = 0.00), Teste de Stroop (p = 0.00), Teste do Relógio (p = 0.00), Subteste Dígitos (p = 0.00) e Raciocínio matricial da WAIS-III (p = 0.01). Após ajuste estatístico através de Regressão Linear, a migrânea se manteve como único fator relevante para pior desempenho em MoCA, Fluência verbal, Teste do relógio e Teste de Stroop.

Conclusão: Pacientes com migrânea crçnica apresentam déficits cognitivos incluindo múltiplas tarefas, independentes da presença de comorbidades e uso de medicações.

Keywords:

headache - migraine disorders - cognitive dysfunction

Palavras-chave:

cefaleia - transtornos de enxaqueca - disfunção cognitiva


Publication History

Received: 21 December 2017

Accepted: 23 May 2018

Article published online:
22 August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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