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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(11): 731-735
DOI: 10.1590/0004-282X20180114
Article

Restless legs syndrome in Parkinson's disease and increased cardiovascular risk

Síndrome das pernas inquietas em doença de Parkinson e aumento do risco cardiovascular
Maren de Moraes e Silva
1   Hospital da Cruz Vermelha Brasileira Filial do Paraná, Departamento de Neurologia, Curitiba PR, Brasil
,
Cezar Henrique Lorenzi
2   Universidade Federal do Paraná, Curitiba PR, Brasil
,
Blenda Barreto Schneider
3   Universidade Positivo, Curitiba PR, Brasil
,
Catherine Enk Fischer Seidel
4   Faculdade Evangélica do Paraná, Curitiba PR, Brasil
,
Isabela Salomé
5   Pontifícia Universidade Católica do Paraná, Curitiba PR, Brasil
,
Viktor Cleto Morais Gianini
6   Faculdades Pequeno Príncipe, Curitiba PR, Brasil
,
Renata Ramina Pessoa
1   Hospital da Cruz Vermelha Brasileira Filial do Paraná, Departamento de Neurologia, Curitiba PR, Brasil
,
Pilar Bueno Siqueira Mercer
1   Hospital da Cruz Vermelha Brasileira Filial do Paraná, Departamento de Neurologia, Curitiba PR, Brasil
,
Maria Carolina Zavagna Witt
1   Hospital da Cruz Vermelha Brasileira Filial do Paraná, Departamento de Neurologia, Curitiba PR, Brasil
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ABSTRACT

Restless legs syndrome (RLS) is a disorder commonly found in patients with Parkinson's disease, with descriptions for both conditions impairing dopaminergic transmission in central nervous system. Previous studies in varied populations indicate an association between the presence of RLS and increased cardiovascular risk and, so far, there are no consistent studies of this association in Parkinson's disease.

Objective: To analyze the influence of RLS on cardiovascular risk in patients with Parkinson's disease.

Methods: We reviewed the medical records of 202 patients diagnosed with Parkinson's disease and verified the presence of RLS, cardiovascular comorbidities, blood pressure measurements, lipid profiles and Framingham Risk Scores.

Results: Statistically significant higher values of total cholesterol were found for the RLS group (mean 216.6 mg/dL), as well as for LDL cholesterol (mean 145 mg/dL). No statistical difference was found among the other factors.

Conclusion: Patients with Parkinson's disease and RLS have a higher prevalence of dyslipidemia than patients without RLS, suggesting a correlation between restless legs and hyperlipidemia. It is questioned whether the dopaminergic substrate is the main factor in the genesis of the syndrome, as even with the use of dopaminergic agonists by both groups, it was possible to observe differences between groups. The hypothesis of the real interference of the syndrome treatment as a protective factor for cardiovascular risk was generated.

RESUMO

Síndrome das pernas inquietas é um distúrbio comumente encontrado em pacientes com doença de Parkinson (DP), havendo descrições para ambas as condições de prejuízos na transmissão dopaminérgica no sistema nervoso central. Estudos prévios em populações diversas indicam associação entre a presença da síndrome e aumento do risco cardiovascular, não havendo, até o momento, pesquisas consistentes a respeito desta associação em DP.

Objetivo: Analisar a influência da síndrome das pernas inquietas no risco cardiovascular em pacientes com DP.

Métodos: Foram revisados prontuários de 202 pacientes com diagnóstico de DP e verificada a presença de síndrome das pernas inquietas, comorbidades cardiovasculares, aferições de pressão arterial, lipidograma e escore de Framingham.

Resultados: Valores maiores e estatisticamente significativos de colesterol total foram encontrados para o grupo com pernas inquietas (média de 216.6 mg/dL), assim como para colesterol LDL (média de 145 mg/dL). Não foi encontrada diferença estatística entre os demais fatores.

Conclusões: Pacientes com DP e síndrome das pernas inquietas têm maior prevalência de dislipidemia do que pacientes sem a síndrome, o que sugere correlação entre síndrome das pernas inquietas e hiperlipidemia. É posto em prova o substrato dopaminérgico como principal na gênese da síndrome, uma vez que, mesmo sob o uso de agonistas dopaminérgicos por ambos os grupos, foi possível observar diferenças entre os estratos. Gerada a hipótese da real interferência do tratamento da síndrome como fator de proteção para o risco cardiovascular.

Keywords:

Parkinson disease - restless legs syndrome - cardiovascular diseases - dyslipidemias

Palavras-chave:

Doença de Parkinson - síndrome das pernas inquietas - doenças cardiovasculares - dislipidemias

Support

Financial support was responsibility of the authors themselves, and there was no external source of funding for this paper.




Publication History

Received: 14 May 2018

Accepted: 29 July 2018

Article published online:
22 August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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