RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00035023.xml
PDF herunterladen
Vet Comp Orthop Traumatol 2011; 24(04): 262-265
DOI: 10.3415/VCOT-11-03-0048
DOI: 10.3415/VCOT-11-03-0048
Original Research
Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complex
Financial Support Received: This work was funded in part by an award to DNC and LJK from the British Veterinary Orthopaedic Association.
Weitere Informationen
Publikationsverlauf
Received:28. März 2011
Accepted:05. Mai 2011
Publikationsdatum:
21. Dezember 2017 (online)
Summary
Objectives: To investigate the association of the major histocompatability (MHC) class II allele haplotype frequencies with the diagnosis of cranial cruciate ligament (CCL) rupture in two breeds of dog.
Methods: DNA samples from populations of Labrador Retrievers and Golden Retrievers with CCL rupture and general populations of the same breeds were characterised for three DLA class II loci (DRB1*, DQA1* and DQB1*) alleles using sequence-based typing or reference strand-mediated conformation analysis.
Results: Although distinct differences in haplotype types, frequencies and homozygozity were observed between the two breeds, no disease specific association could be identified for the development of the CCL rupture within either population.
Clinical significance: The risk for developing CCL rupture was not associated with DLA haplotype group(s) in Labrador Retrievers or Golden Retrievers, thus the hypothesis that there is an autoimmune basis to CCL rupture was not supported.
-
References
- 1 Bennett D, Tennant B, Lewis DG. et al. A reappraisal of anterior cruciate ligament disease in the dog. J Small Anim Pract 1988; 29: 275-297.
- 2 Comerford EJ, Tarlton JF, Innes JF. et al. Metabolism and composition of the canine anterior cruciate ligament relate to differences in knee joint mechanics and predisposition to ligament rupture. J Orthop Res 2005; 23: 61-66.
- 3 Whitehair JG, Vasseur PB, Willits NH.. Epidemiology of cranial cruciate ligament rupture in dogs. J Am Vet Med Assoc 1993; 203: 1016-1019.
- 4 Wilke VL, Conzemius MG, Kinghorn BP. et al. Inheritance of rupture of the cranial cruciate ligament in Newfoundlands. J Am Vet Med Assoc 2006; 228: 61-64.
- 5 Nielen AL, Knol BW, van Hagen MA. et al. Genetic and epidemiological investigation of a birth cohort of boxers. Tijdschr Diergeneeskd 2003; 128: 586-590.
- 6 Vasseur PB, Pool RR, Arnoczky SP. et al. Correlative biomechanical and histologic study of the cranial cruciate ligament in dogs. Am J Vet Res 1985; 46: 1842-1854.
- 7 Laros GS, Tipton CM, Cooper RR.. Influence of physical activity on ligament insertions in the knees of dogs. Journal of Bone and Joint Surgery (American) 1971; 53: 275-286.
- 8 Read RA, Robins GM.. Deformity of the proximal tibia in dogs. Vet Rec 1982; 111: 295-298.
- 9 Comerford EJ, Tarlton JF, Avery NC. et al. Distal femoral intercondylar notch dimensions and their relationship to composition and metabolism of the canine anterior cruciate ligament. Osteoarthritis Cartilage 2006; 14: 273-278.
- 10 Aiken SW, Kass PH, Toombs JP.. Intercondylar notch width in dogs with and without cranial cruciate ligament injuries. Vet Comp Orthop Traumatol 1995; 8: 128-132.
- 11 Slauterbeck JR, Pankratz K, Xu KT. et al. Canine ovariohysterectomy and orchiectomy increases the prevalence of ACL injury. Clin Orthop Relat Res 2004; 429: 301-305.
- 12 Niebauer GW, Wolf B, Bashey RI. et al. Antibodies to canine collagen types I and II in dogs with spontaneous cruciate ligament rupture and osteoarthritis. Arthritis Rheum 1987; 30: 319-327.
- 13 Bari AS, Carter SD, Bell SC. et al. Anti-type II collagen antibody in naturally occurring canine joint diseases. Br J Rheumatol 1989; 28: 480-486.
- 14 de Rooster H, Cox E, van Bree H.. Prevalence and relevance of antibodies to type-I and -II collagen in synovial fluid of dogs with cranial cruciate ligament damage. Am J Vet Res 2000; 61: 1456-1461.
- 15 Carter SD, Bell SC, Bari AS. et al. Immune complexes and rheumatoid factors in canine arthritides. Ann Rheum Dis 1989; 48: 986-991.
- 16 Lemburg AK, Meyer-Lindenberg A, HewickerTrautwein M.. Immunohistochemical characterization of inflammatory cell populations and adhesion molecule expression in synovial membranes from dogs with spontaneous cranial cruciate ligament rupture. Vet Immunol Immunopathol 2004; 97: 231-240.
- 17 Hegemann N, Wondimu A, Kohn B. et al. Cytokine profile in canine immune-mediated polyarthritis and osteoarthritis. Vet Comp Orthop Traumatol 2005; 18: 67-72.
- 18 Logunova NN, Viret C, Pobezinsky LA. et al. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Expo Med 2005; 202: 73-84.
- 19 Fernando MMA, Stevens CR, Walsh EC. et al. Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis. PLoS Genet 2008; 4: e1000024.
- 20 Ollier WE, Kennedy LJ, Thomson W. et al. Dog MHC alleles containing the human RA shared epitope confer susceptibility to canine rheumatoid arthritis. Immunogenetics 2001; 53: 669-673.
- 21 Jacobson EM, Huber A, Tomer Y.. The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology. J Autoimmun 2008; 30: 58-62.
- 22 Kennedy LJ, Davison LJ, Barnes A. et al. Identification of susceptibility and protective major histo-compatibility complex haplotypes in canine diabetes mellitus. Tissue Antigens 2006; 68: 467-476.
- 23 Kennedy LJ, O'Neill T, House A. et al. Risk of anal furunculosis in German Shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens 2008; 71: 51-56.
- 24 Kennedy LJ, Quarmby S, Happ GM. et al. Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele. Tissue Antigens 2006; 68: 82-86.
- 25 UK DNA Archive for Companion Animals 2011. [cited on 2011 March 23]. Available from. http://pcwww.liv.ac.uk/DNA_Archive_for_Companion_Animals
- 26 Clements DN, Wood S, Carter SD. et al. Assessment of the quality and quantity of genomic DNA recovered from canine blood samples by three different extraction methods. Res Vet Sci 2008; 85: 74-79.
- 27 Kennedy LJ, Barnes A, Happ GM. et al. Evidence for extensive DLA polymorphism in different dog populations. Tissue Antigens 2002; 60: 43-52.
- 28 Kennedy LJ, Quarmby S, Fretwell N. et al. High-Resolution Characterization of the Canine DLA-DRB1 Locus Using Reference Strand-Mediated Conformational Analysis. J Hered 2005; 96: 836-842.
- 29 Dupont WD, Plummer WD.. PS power and sample size program available for free on the Internet. Control Clin Trials 1997; 18: 274.
- 30 Hughes AM, Jokinen P, Bannasch DL. et al. Association of a dog leukocyte antigen class II haplotype with hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers. Tissue Antigens 2010; 75: 684-690.
- 31 Wilbe M, Jokinen P, Hermanrud C. et al. MHC class II polymorphism is associated with a canine SLE-related disease complex. Immunogenetics 2009; 61: 557-564.
- 32 Sutter NB, Eberle MA, Parker HG. et al. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res 2004; 14: 2388-2396.