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CC BY 4.0 · AIMS Genet 2014; 01(01): 020-033
DOI: 10.3934/genet.2014.1.20
Review

Context-dependent interplay between Hippo and JNK pathway in Drosophila

Authors

  • Xianjue Ma

    1   Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Abstract

Both Hippo and JNK signaling have well-established roles in regulating many physiological processes, including cell proliferation, growth, survival, and migration. An increasing body of evidence shows that dysregulation of either Hippo or JNK pathway would lead to tumorigenesis. Recently, studies in Drosophila has coupled Hippo with JNK pathway in numerous ways ranging from tissue regeneration to growth control. In this review, I provide an overview of the current understanding of crosstalk between Hippo and JNK pathway in Drosophila, and discuss their context-dependent interactions in gut homeostasis, regeneration, cell competition and migration.

Keywords

Hippo - JNK - Drosophila - cell competition - ISC - migration


Publication History

Received: 28 October 2014

Accepted: 08 December 2014

Article published online:
10 May 2021

© 2014. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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