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CC BY 4.0 · AIMS Genet 2015; 02(01): 013-024
DOI: 10.3934/genet.2015.1.13
Review

Neural stem cell derived tumourigenesis

Francesca Froldi
1   Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
2   Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, 3010, Australia
,
Milán Szuperák
1   Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
2   Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, 3010, Australia
,
Louise Y. Cheng
1   Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
2   Sir Peter MacCallum Department of Oncology, University of Melbourne, Victoria, 3010, Australia
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Abstract

In the developing Drosophila CNS, two pools of neural stem cells, the symmetrically dividing progenitors in the neuroepithelium (NE) and the asymmetrically dividing neuroblasts (NBs) generate the majority of the neurons that make up the adult central nervous system (CNS). The generation of a correct sized brain depends on maintaining the fine balance between neural stem cell self-renewal and differentiation, which are regulated by cell-intrinsic and cell-extrinsic cues. In this review, we will discuss our current understanding of how self-renewal and differentiation are regulated in the two neural stem cell pools, and the consequences of the deregulation of these processes.

Keywords

Drosophila - stem cell - neuroblast - neuroepithelia - proliferation - differentiation - self-renewal


Publication History

Received: 23 November 2014

Accepted: 11 January 2015

Article published online:
10 May 2021

© 2015. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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