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CC BY 4.0 · AIMS Genet 2015; 02(04): 250-262
DOI: 10.3934/genet.2015.4.250
Research article

Associations of CYP1A1 gene polymorphisms and risk of breast cancer in Indian women: a meta-analysis

Noel Pabalan
1   Center for Research and Development, Angeles University Foundation, Angeles City 2009, Philippines
,
Neetu Singh
2   Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow 226 001, Utar Pradesh, India
,
Eloisa Singian
3   College of Allied Medical Profession, Angeles University Foundation, Angeles City 2009 Philippines
,
Caio Parente Barbosa
4   Department of Gynecology and Obstetrics-Faculdade de Medicina do ABC, Human Reproduction and Genetics Center, Avenida Prıncipe de Gales, 821, Santo Andre, SP, 09060-650, Brazil
,
Bianca Bianco
4   Department of Gynecology and Obstetrics-Faculdade de Medicina do ABC, Human Reproduction and Genetics Center, Avenida Prıncipe de Gales, 821, Santo Andre, SP, 09060-650, Brazil
,
Hamdi Jarjanazi
5   5 Environmental Monitoring and Reporting Branch, Ontario Ministry of the Environment and Climate Change, 125 Resources Road, Toronto, ON, Canada M9P 3V6
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Abstract

Reported associations of CYP1A1 polymorphisms with breast cancer have been inconsistent. In this meta-analysis examining breast cancer associations of three CYP1A1 polymorphisms (M1, M2 and M4) among Indian women may yield information that may be of clinical and epidemiological use for this particular demography. We searched MEDLINE using PubMed and Embase for association studies. From seven published case-control studies, we estimated overall associations and applied subgroup analysis to explore differential effects. All three polymorphisms exhibited overall increased risk, significant in M1 (OR 1.61–1.65, p = 0.04) and M4 (OR 2.02–3.92, p = 0.02–0.04). Differential effects were observed only in the M1 polymorphism where M1 effects were significant in South Indians (OR 2.20–4.34, p < 0.0001) but not the North population, who were at reduced risk (OR 0.64–0.77, p = 0.03–0.55). These populations were not materially different in regard to M2 and M4 as did the women stratified by menopausal status. In this meta-analysis, M1 and M4 effects may render Indian women susceptible, but may be limited by heterogeneity of the studies. Differential effects of the M1 polymorphism in breast cancer render South Indians susceptible compared to those in the North.

Keywords

diatoms - breast cancer - CYP1A1 - meta-analysis - polymorphisms


Publication History

Received: 06 August 2015

Accepted: 15 October 2015

Article published online:
10 May 2021

© 2015. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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