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CC BY 4.0 · AIMS Genet 2019; 06(02): 011-013
DOI: 10.3934/genet.2019.2.11
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Linking metabolic and epigenetic regulation in the development of lung cancer driven by TGFβ signaling

Liyi Zhang
1   Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P. R. China
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Abbreviations

FH: Fumarase
NICD: Notch intracellular domain



Publikationsverlauf

Eingereicht: 31. Mai 2019

Angenommen: 31. Mai 2019

Artikel online veröffentlicht:
15. März 2021

© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Lu S, Wang Y. Nonmetabolic functions of metabolic enzymes in cancer development. Cancer Commun 2018; 38: 63
    CrossrefPubMedGoogle Scholar
  • 2 Wang Y, Lei Q. Metabolic recoding of epigenetics in cancer. Cancer Commun 2018; 38: 25
    CrossrefPubMedGoogle Scholar
  • 3 Xiao M, Yang H, Xu W. et al. Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 2012; 26: 1326-1338
    CrossrefPubMedGoogle Scholar
  • 4 Sciacovelli M, Goncalves E, Johnson TI. et al. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature 2016; 537: 544-547
    Google Scholar
  • 5 Wang T, Yu Q, Li J. et al. O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency. Nature Cell Biol 2017; 19: 833-843
    CrossrefPubMedGoogle Scholar
  • 6 Horowitz JC, Lee DY, Waghray M. et al. Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J Biological Chem 2004; 279: 1359-1367
    CrossrefPubMedGoogle Scholar
  • 7 Timmerman LA, Grego-Bessa J, Raya A. et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 2004; 18: 99-115
    CrossrefPubMedGoogle Scholar
  • 8 Procopio MG, Laszlo C, Al Labban D. et al. Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation. Nature Cell Biol 2015; 17: 1193-1204
    CrossrefPubMedGoogle Scholar
  • 9 Chen T, Wang T, Liang W. et al. PAK4 Phosphorylates Fumarase and Blocks TGFbeta-Induced Cell Growth Arrest in Lung Cancer Cells. Cancer Res 2019; 79: 1383-1397
    CrossrefPubMedGoogle Scholar
  • 10 Jiang Y, Qian X, Shen J. et al. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biol 2015; 17: 1158-1168
    CrossrefPubMedGoogle Scholar