CC BY-NC-ND 4.0 · Indian J Plast Surg 2012; 45(02): 215-219
DOI: 10.4103/0970-0358.101281
Original Article
Association of Plastic Surgeons of India

Effect of static magnetic field on experimental dermal wound strength

Yahya Ekici
Departments of General Surgery, Ankara, Turkey
,
Cem Aydogan
Departments of General Surgery, Ankara, Turkey
,
Cenk Balcik
Departments of Mechanical Engineering, Ankara, Turkey
,
Nihan Haberal
Departments of Pathology, Baskent University, Ankara, Turkey
,
Mahir Kirnap
Departments of General Surgery, Ankara, Turkey
,
Gokhan Moray
Departments of General Surgery, Ankara, Turkey
,
Mehmet Haberal
Departments of General Surgery, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
27 November 2019 (online)

ABSTRACT

Context: An animal model. Aim: We sought to evaluate the effect of static magnetic fields on cutaneous wound healing. Materials and Methods: Male Wistar rats were used. Wounds were created on the backs of all rats. Forty of these animals (M group) had NeFeB magnets placed in contact with the incisions, either parallel (Pa) and perpendicular (Pr) to the incision. The other 40 animals (sham [S] group) had nonmagnetized NeFeB bars placed in the same directions as the implanted animals. Half of the animals in each group were killed and assessed for healing on postoperative day 7 and the other half on postoperative day 14. The following assessments were done: gross healing, mechanical strength, and histopathology. Statistical Analysis Used: Intergroup differences were compared by using the Mann-Whitney U or t test. Values for P less than 0.05 were accepted as significant. Results and Conclusions: There were no differences between the magnetic and sham animals with respect to gross healing parameters. The mechanical strength was different between groups. On postoperative day 14, the MPr14 had significantly higher scores than the other groups. When static, high-power, magnetic fields are placed perpendicular to the wound, increased wound healing occurs in the skin of the experimental model.

 
  • 1 Peackok EE, Cohen IK. Wound healing. In: McCarthy JG, May JW, Littler JW, editors. Plasticsurgery. Philadelphia: WB Saunders; 1990. p. 161-85.
  • 2 Poffenbarger PL, Haberal MA. Role of serum nonsuppressible insulin-like activity (NSILA) in wound healing. I. Influence of thyroparathyroidectomy on serum NSILA and wound healing in the rat. Surgery1976;80:608-16.
  • 3 Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, et al. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg 2008;121:130-41.
  • 4 Muehlberger T, Moresi JM, Schwarze H, Hristopoulos G, Laenger F, Wong L. The effect of topical tretinoin on tissue strength and skin components in a murine incisional wound model. J Am Acad Dermatol 2005;52:583-8.
  • 5 Darendeliler MA, Darendeliler A, Sinclair PM. Effects of static magnetic and pulsed electromagnetic fields on bone healing. Int J Adult Orthodon Orthognath Surg 1997;12:43-53.
  • 6 Bertolino G, de Freitas Braga A, de Oliveira Lima do Couto Rosa K, de Brito Junior LC, de Araujo JE. Macroscopic and histological effects of magnetic field exposition in the process of tissue reparation in Wistar rats. Arch Dermatol Res 2006;298:121-6.
  • 7 Kelleher MO, Al-Abri RK, Lenihan DV, Glasby MA. Use of a static magnetic field to promote recovery after peripheral nerve injury. J Neurosurg 2006;105:610-5.
  • 8 Henry SL, Concannon MJ, Yee GJ. The effect of magnetic fields on wound healing: experimental study and review of the literature. Eplasty 2008;8:e40.
  • 9 Aydin N, Bezer M. The effect of an intramedullary implant with a static magnetic field on the healing of the osteotomised rabbit femur. Int Orthop 2011;35:135-41.
  • 10 Rosen AD. Effect of a 125 mT static magnetic field on the kinetics of voltage activated Na+ channels in GH3 cells. Bioelectromagnetics 2003;24:517-23.
  • 11 Miyakoshi J. Effects of static magnetic fields at the cellular level. Prog Biophys Mol Biol 2005;87:213-23.
  • 12 Murayama M. Orientation of sickled erythrocytes in a magnetic field. Nature 1965;206:420-2.
  • 13 Higashi T, Yamagishi A, Takeuchi T, Kawaguchi N, Sagawa S, Onishi S, et al. Orientation of erythrocytes in a strong static magnetic field. Blood 1993;82:1328-34.
  • 14 Emura R, Takeuchi T, Nakaoka Y, Higashi T. Analysis of anisotropic diamagnetic susceptibility of a bull sperm. Bioelectromagnetics 2003;24:347-55.
  • 15 Guido S, Tranquillo RT. A methodology for the systematic and quantitative study of cell contact guidance in oriented collagen gels. Correlation of fibroblast orientation and gel birefringence. J Cell Sci 1993;105(Pt 2):317-31.
  • 16 Hirose H, Nakahara T, Miyakoshi J. Orientation of human glioblastoma cells embedded in type I collagen, caused by exposure to a 10 T static magnetic field. Neurosci Lett 2003;338:88-90.
  • 17 Man D, Man B, Plosker H. The influence of permanent magnetic field therapy on wound healing in suction lipectomy patients: a double-blind study. Plast Reconstr Surg 1999;104:2261-6; discussion 2267-8.
  • 18 Mayrovitz HN, Groseclose EE. Effects of a static magnetic field of either polarity on skin microcirculation. Microvasc Res 2005;69:24-7.
  • 19 Morris CE, Skalak TC. Acute exposure to a moderate strength static magnetic field reduces edema formation in rats. Am J Physiol Heart Circ Physiol 2008;294:H50-7.
  • 20 Zhao M, Pu J, Forrester JV, McCaig CD. Membrane lipids, EGF receptors, and intracellular signals colocalize and are polarized in epithelial cells moving directionally in a physiological electric field. FASEB J 2002;16:857-9.
  • 21 Buemi M, Marino D, Di Pasquale G, Floccari F, Senatore M, Aloisi C, et al. Cell proliferation/cell death balance in renal cell cultures after exposure to a static magnetic field. Nephron 2001;87:269-73.
  • 22 Schiffer IB, Schreiber WG, Graf R, Schreiber EM, Jung D, Rose DM, et al. No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI. Bioelectromagnetics 2003;24:241-50.
  • 23 Yamaguchi H, Hosokawa K, Soda A, Miyamoto H, Kinouchi Y. Effects of seven months′ exposure to a static 0.2 T magnetic field on growth and glycolytic activity of human gingival fibroblasts. Biochim Biophys Acta 1993;1156:302-6.
  • 24 Teodori L, Grabarek J, Smolewski P, Ghibelli L, Bergamaschi A, De Nicola M, et al. Exposure of cells to static magnetic field accelerates loss of integrity of plasma membrane during apoptosis. Cytometry 2002;49:113-8.
  • 25 Flipo D, Fournier M, Benquet C, Roux P, Le Boulaire C, Pinsky C, et al. Increased apoptosis, changes in intracellular Ca2+, and functional alterations in lymphocytes and macrophages after in vitro exposure to static magnetic field. J Toxicol Environ Health A 1998;54:63-76.