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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2012; 33(04): 224-226
DOI: 10.4103/0971-5851.107087
ORIGINAL ARTICLE

Evaluation of micronutrient status in serum and saliva of oral submucous fibrosis patients: A clinicopathological study

Shishir Ram Shetty
Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, India
,
Subhas Babu
Department of Oral Medicine and Radiology, AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, India
,
Suchetha Kumari
Department of Biochemistry, KS Hegde Medical Academy, Mangalore, Karnataka, India
,
Pushparaja Shetty
Department of Oral Pathology, AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India
,
R Vijay
Central Research Laboratory, Nitte University, Mangalore, Karnataka, India
,
Arvind Karikal
Department of Oral Surgery, AB Shetty Memorial Institute of Dental Science, Mangalore, Karnataka, India
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Abstract

Background: Oral submucous fibrosis (OSMF) is one of the most commonly occurring potentially malignant disorders in India and south East Asian countries where betel chewing is common practice. Iron and ascorbic acid are important agents for collagen synthesis. Aims: The aims of this study were to estimate the levels of iron and ascorbic acid in serum and saliva in patients with OSMF and to correlate change in levels of iron and ascorbic acid with the histopathological grading of OSMF. Materials and Methods: The study group comprised of 65 clinically diagnosed and histopathologically confirmed cases of OSMF; 21 age- and sex-matched controls were also enrolled in the study. Serum and salivary ascorbic acid were analyzed by the dintrophenyl hydrazine method whereas serum and salivary iron were analyzed by the dipyridyl method. Results: The serum and salivary ascorbic acid levels consistently decreased with the progression of histopathologiocal grading of OSMF. Serum and salivary iron levels were also decreased in OSMF patients, but this was not significant. Conclusion: Ascorbic acid and iron may have been used for the excessive collagen synthesis occurring during progression of OSMF. Hence, serum and salivary monitoring may play a crucial role in the early diagnosis and prognosis of OSMF.

Keywords

Ascorbic acid - collagen - iron - oral submucous fibrosis - saliva


Publication History

Article published online:
20 July 2021

© 2012. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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