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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2017; 38(01): 84-87
DOI: 10.4103/0971-5851.203491
Practitioner Section

Primitive Neuroectodermal Tumor of Lung in Adult with Hemorrhagic Brain Metastasis: An Extremely Rare Case Scenario

Abhishek Purkayastha
Department of Radiation Oncology, Army Hospital (Research and Referral), New Delhi, India
,
Neelam Sharma
Department of Radiation Oncology, Army Hospital (Research and Referral), New Delhi, India
,
Amul Kapur
Department of Medical Oncology, Army Hospital (Research and Referral), New Delhi, India
,
Kavita Sahai
Department of Pathology and Molecular Science, Army Hospital (Research and Referral), New Delhi, India
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Abstract

Primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms of embryonal origin manifesting in children and adolescents, rarely seen in adults. Carcinoma lung with hemorrhagic metastasis to the brain is very common, but primary lung PNET with hemorrhagic brain metastasis is extremely uncommon. We hereby report a 29-year-old female diagnosed as PNET lung was treated with vincristine, adriamycin, and cyclophosphamide alternating with ifosfamide plus etoposide followed by radiotherapy (RT). After 9 months, she developed hemorrhagic brain metastasis from PNET lung confirmed from tissue immunohistology postcraniotomy. Received palliative whole brain RT followed by oral pazopanib resulting in significant improvement in performance status. A thorough review of literature reveals that our case may be the second case of primary lung PNET with hemorrhagic brain metastasis and also thefirst to be exhibited oral pazopanib resulting in a significant therapeutic effect to be reported in world literature till date.

Keywords

Hemorrhagic brain metastasis - lung - pazopanib - primitive neuroectodermal tumor - whole brain radiotherapy


Publikationsverlauf

Artikel online veröffentlicht:
06. Juli 2021

© 2017. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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