PDF herunterladen
CC BY-NC-ND 4.0 · J Lab Physicians 2013; 5(01): 30-33
DOI: 10.4103/0974-2727.115923
Original Article

Evaluation of Serum Zinc Status and Glycated Hemoglobin of Type 2 Diabetes Mellitus Patients in a Tertiary Care Hospital of Assam

Gautom Kumar Saharia
Departments of Biochemistry, NEIGRIHMS, Shillong, Meghalaya, India
,
Rohini Kanta Goswami
Departments of Assam Medical College and Hospital, Dibrugarh, Assam, India
› Institutsangaben Source of Support: Institute Thesis Grant of Rs 4000/- (Rupees four thousand only) and existing facility at the Department of Biochemistry, Assam Medical College Dibrugarh.
› Weitere Informationen
Auch verfügbar auf
  als PDF herunterladen Lizenzen und Reprints

ABSTRACT

The present study was undertaken to find out any correlation between serum zinc concentration and HbA1C% in patients with type 2 diabetes mellitus (DM). The study was carried out on 50 newly diagnosed patients of type 2 diabetes and controls in the Department of Biochemistry, Assam Medical College and Hospital, Dibrugarh. Analyses of blood glucose (fasting and postprandial), glycated hemoglobin (HbA1c), serum zinc, urea, and creatinine concentrations were performed by standard methods. Concentrations of fasting and postprandial blood glucose were significantly higher in the diabetic group than controls (P < 0.001) and the mean HbA1c% was also higher in cases (8.32% ±1.58%). The mean serum zinc concentration in cases was found to be significantly lower than controls (79.85 ± 13.4 vs. 109.74 ± 9.72 μg/dL) and P < 0.001 with correlation coefficient r = –0.804. Present study revealed an inverse relationship between HbA1C% and serum zinc concentration in patients with type 2 DM, substantiated by regression analysis.

Key words:

Assam - serum zinc, HbA1C% - type 2 diabetes mellitus


Publikationsverlauf

Artikel online veröffentlicht:
07. April 2020

© 2013.

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • REFERENCES

  • 1 Zimmet P, Alberti KG, Shaw J. Global and Societal Implication of the Diabetes Epidemic. Nature 2001;414:782-7.
  • 2 Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998;17:109-115.
  • 3 Rai V, Iyer U, Mani I, Mani UV. Serum Biochemical changes in Insulin Dependent and Noninsulin Dependent Diabetes Mellitus and their role in the Development of Secondary Complications. Int J Diabetes Dev Ctries 1997;17:33-7.
  • 4 Tripathy S, Sumathi S, Bhupal Raj G. Minerals Nutritional Status of Type 2 Diabetic Subjects. Int J Diabetes Dev Ctries 2004;24:27-8.
  • 5 Hyun-Mee Oh, Jin-Sook Yoon. Glycemic control of type 2 diabetic patients after short-term zinc supplementation. Nutrition Research and Practice 2008;2:283-8.
  • 6 Diabetes Control and Complications Trial Research Group. 'The relationship of glycemic exposure (HbA1C) to the risk of development and progression of retinopathy in the diabetes control and complications trial', Diabetes 1995;44;968.
  • 7 Nathan DM, Singer DE, Hurxthal K, Goodson JD. The clinical information value of the glycosylated hemoglobin assay. N Engl J Med 1984;310:341-6.
  • 8 American Diabetes Association: Standards of medical care in diabetes; Diabetes Care 2010;33(Suppl 1):S13.
  • 9 Akita Abe, Yiamashita S. Clin Chem 1989;35/4:552-4.
  • 10 Tetsuo Makino. Clin Chem Acta 1991;197:209-20.
  • 11 Trivelli LA, RanneyHM, Lai HT. Hemoglobin components in patients with diabetes mellitus. N Engl J Med 1971;284:353-7.
  • 12 Bunn HF. Evaluation of glycosylated hemoglobin in diabetic patients. Diabetes 1981;30:613-17.
  • 13 Trinder P. Glucose oxidase-peroxidase method. Ann Clin Biochem. 1964;6:24
  • 14 Raabo E, Terkildsen TC. On the enzymatic determination of blood glucose. Scand J Clin Lab Invest 1960;12:402-07.
  • 15 Berthelot MP. Berthelot's reaction mechanism. Report Chim Appl 1859;2884.
  • 16 Fawcett JK Scott JE J Chim Pathol 1960;13:156.
  • 17 Bosnes RW, Taussy HH. On the colorimetric determination of creatinine by the Jaffe reaction. J Biol Chem 1945;158:581-91.
  • 18 Toro G, Ackermann PG. Practical Clinical Chemistry. Boston: Little Brown and Co; 1975. p. 154.
  • 19 Kinlaw WB, Levine S, Morley J, Silvis S, McClain C. Abnormal Zn metabolism in type II diabetes mellitus. Am J Med 1983;75:273-7.
  • 20 Zalewski P, Millard S, Forbes I, Kapaniris O, Slavotinek S, Betts W, Ward A, et al. Video image analysis of labile Zn in viable pancreatic islet cells using specific fluorescent probe for Zn. J Histochem Cytochem 1994;42:877-84.
  • 21 Williams NR, Rajput-Williams J, West J, Nigdikar S, Foote J, Howard A. Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus. Analyst 1995;120:887-90.
  • 22 McNair P, Kiilerich S, Christiansen C, Christiansen M, Madsbad S, Transbol I. Hyperzincuria in insulin treated diabetes mellitus-its relation to glucose homeostasis and insulin administration. Clinica Chimica Acta 1981;112:343-8.
  • 23 Garg V, Gupta R, Goal R. Hypozincemia in diabetes mellitus. J Assoc Physicians India 1994;42:720-1.
  • 24 The Diabetes Control and Complications Trial Research Group. N Engl J Med 1993;329:977-86.
  • 25 Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38 BMJ 1998;317:703.
  • 26 Khaw KT. Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and nutrition (EPIC-Norfolk). BMJ 2001;322:15-18.
  • 27 Verma. Effect of Increasing Duration of Diabetes Mellitus Type 2 on Glycated Hemoglobin And Insulin Sensitivity, Indian J Clin Biochem 2006;21:142-6.
  • 28 Refaat A. Al-Maroof, Shatha S. Al-Sharbatti; Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of type 2 diabetics. Saudi Med J 2006;27:344-50.
  • 29 Marchesini G, Bugianesi E, Ronchi M, Flamia R, Thomaseth K, Pacini G. Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism 1998;47:792-8.