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CC BY-NC-ND 4.0 · J Lab Physicians 2014; 6(02): 127-129
DOI: 10.4103/0974-2727.141516
Case Report

Cryoglobulinemia as an Initial Manifestation of Underlying Hematological Malignancy: A Rare Occurrence in India

Narender Kumar
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Reena Das
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Dinesh Chandra
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Pankaj Malhotra
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
› Author Affiliations Source of Support: Nil
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ABSTRACT

Cryoglobulinemias rarely been reported from India even though associated conditions such as hepatitis C infection, rheumatoid arthritis and plasma cell dyscrasias, etc., are common occurrences. In many regions of the country, temperatures in winter can be conducive to the precipitation of cryoglobulins, yet epidemiology of the disease suggests that it is a common condition in the west. We encountered a 68-year-old-male patient who presented with a history of headache off and on along with hepatosplenomegaly. The rare occurrence of cryoglobulinemia in our setting can delay the diagnosis, as happened in our case, since the index of suspicion of clinicians and laboratory personnel is low. We are reporting this case because of the rarity and protean clinical manifestations of cryoglobulinemia.

Keywords

Cryoglobulin - cryoglobulinemia - lymphoplasmacytic lymphoma - rouleaux formation


Publication History

Article published online:
19 April 2020

© 2014.

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  • REFERENCES

  • 1 Sansonno D, Dammacco F. Hepatitis C virus, cryoglobulinaemia, and vasculitis: Immune complex relations. Lancet Infect Dis 2005;5:227-36.
  • 2 Ferri C, Zignego AL, Pileri SA. Cryoglobulins. J Clin Pathol 2002;55:4-13.
  • 3 Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M. Biologic and clinical significance of cryoglobulins. A report of 86 cases. Am J Med 1974;57:775-88.
  • 4 Malaviya AN, Narayanan K, Taneja RL, Dixit D. Some observations on cryoproteinemia (from India). Aspect Allergy Appl Imrnunol 1981;13:36-40.
  • 5 Jain R, Bansal R, Malaviya AN. Clinical and immunological profile of cryoglobulinaemia in North India. Asian Pac J Allergy Immunol 1984;2:227-31.
  • 6 Bauermeister DE. Quantitation of bone marrow reticulin - A normal range. Am J Clin Pathol 1971;56:24-31.
  • 7 Rieu V, Cohen P, André MH, Mouthon L, Godmer P, Jarrousse B, et al. Characteristics and outcome of 49 patients with symptomatic cryoglobulinaemia. Rheumatology (Oxford) 2002;41:290-300.
  • 8 Trendelenburg M, Schifferli JA. Cryoglobulins are not essential. Ann Rheum Dis 1998;57:3-5.