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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2015; 07(06): 211-218
DOI: 10.4103/1947-489X.210287
Article

Circulating cell adhesion molecules (sICAM-1 and sVCAM-1) and microangiopathy in diabetes mellitus

Mabrouk Ghonaim
1   Department of Laboratory Sciences and Clinical Biotechnology, Faculty of Applied Medical Sciences, Taif University, Saudi Arabia and Department of Microbiology & Immunology, Faculty of Medicine, Menoufiya University, Shebin El-Kom, Egypt
,
Rawhia El-Edel
2   Department of Clinical Pathology, Faculty of Medicine, Menoufiya University, Shebin El-Kom, Egypt
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Background/Aim: Diabetic microvascular complications are not uncommon. This study was done to investigate the relationship between biochemical parameters of diabetes mellitus (DM) and diabetic microangiopathy and serum levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in DM. Patients and methods: The study included 35 type-1 and 25 type-2 DM patients along with 20 age- and sexmatched healthy controls. For each studied subject, thorough clinical examination and laboratory evaluation [fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), and lipid profile (total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides)] were performed. The serum level of C-peptide was estimated by radioimmunoassay (RIA) while levels of sICAM-1 and sVCAM-1 were determined by ELISA. Results: A significant elevation of both sICAM-1 and sVCAM-1 was detected in both type-1 and type-2 DM patients (P<0.001), with no significant difference between the two patient groups. Levels of sICAM-1 and sVCAM-1 in patients with microangiopathy were significantly (p<0.05) higher than that of patients lacking this complication. Patients with microangiopathy had older age and longer duration of DM, but there was no difference between patients with and those without microangiopathy regarding FBS, HbA1c or lipid profile. There was no significant effect of the disease duration on sICAM-1 or sVCAM-1 levels. Moreover, there was no correlation between circulating CAMs and FBS, HbA1c, cholesterol, triglyceride or C-peptide levels. Conclusion: sICAM-1 and sVCAM-1 serum levels are elevated in DM patients and may have a role in pathogenesis of diabetic microvascular complications. They may be predictors for these complications.

Key-words:

Adhesion molecules - diabetes mellitus - microangiopathy - nephropathy - neuropathy - retinopathy - sICAM-1 - sVCAM-1


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Eingereicht: 19. Mai 2014

Angenommen: 12. September 2015

Artikel online veröffentlicht:
07. Juli 2022

© 2015. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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