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CC BY-NC-ND 4.0 · Avicenna J Med 2015; 05(01): 6-10
DOI: 10.4103/2231-0770.148501
ORIGINAL ARTICLE

Association of microalbuminuria with ischemic heart disease in non-diabetic Asian-Indians: A case control study

Sowjanya Naha
Department of Medicine, Kasturba Hospital, Manipal, Karnataka, India
,
Kushal Naha
Department of Medicine, Kasturba Hospital, Manipal, Karnataka, India
,
Vinay R Pandit
Department of Medicine, Kasturba Hospital, Manipal, Karnataka, India
,
R Balasubramanian
Department of Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, India
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Abstract

Context: Microalbuminuria is a known indicator of atherosclerosis and its association with ischemic heart disease (IHD) has been extensively studied in the diabetic population. The significance of urine microalbumin in non-diabetics, however, is yet to be elucidated. Aim: To determine whether an independent association exists between microalbuminuria and IHD in non-diabetic Asian-Indians, and the level of microalbuminuria predictive of concomitant IHD. Materials and Methods: A cross-sectional case-control study was conducted between July 2009 and June 2011. Non-diabetic patients undergoing evaluation for IHD were divided into cases and controls, based on the presence or absence of IHD, respectively. Fifty cases and 50 controls were included, and matched by age, sex, smoking habit, hypertension and body-mass index (BMI). Fasting blood glucose (FBG), fasting lipid profile, and urine microalbumin were recorded for all patients. Results: Mean fasting glucose, mean low density lipoprotein (LDL)-cholesterol and mean urine microalbumin were all significantly higher in cases compared to controls. Urine microalbumin was independently associated with IHD, and microalbumin greater than 12.6 mg/g was predictive of IHD (OR: 13.5; 95% CI, 4.6-39.9; P < 0.001). Conclusion: Urine microalbumin is independently associated with IHD in non-diabetics and levels greater than 12.6 mg/g are predictive of IHD.

Keywords

Asian-Indian - ischemic heart disease - microalbuminuria - non-diabetic


Publication History

Article published online:
09 August 2021

© 2015. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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