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CC BY-NC-ND 4.0 · Avicenna J Med 2015; 05(02): 46-48
DOI: 10.4103/2231-0770.154199
CASE REPORT

Sorafenib induced acral pigmentation: A new entity

Mrinal Gupta
Sudhaa Skin Centre, Jammu, Jammu and Kashmir, India
,
Heena Gupta
Sudhaa Skin Centre, Jammu, Jammu and Kashmir, India
,
Anish Gupta
Sudhaa Skin Centre, Jammu, Jammu and Kashmir, India
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Abstract

Sorafenib is a multikinase inhibitor commonly used for the treatment of advanced renal cell and hepatocellular carcinoma. The commonly reported dermatological adverse effects of Sorafenib include hand-foot syndrome (HFS), alopecia, pruritus, facial and scalp erythema, splinter hemorrhages, keratoacanthomas, squamous cell carcinomas and eruptive melanocytic naevi. We report a case of asymptomatic hyperpigmentation of the palms and soles in a patient receiving Sorafenib therapy for advanced renal cell carcinoma, in the absence of features of classic HFS, which has not been previously reported in the literature.

Keywords

Acral pigmentation - hand foot syndrome - Sorafenib


Publication History

Article published online:
09 August 2021

© 2015. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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