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CC BY-NC-ND 4.0 · Avicenna J Med 2015; 05(03): 83-88
DOI: 10.4103/2231-0770.160242
ORIGINAL ARTICLE

Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography

Rami M Abazid
Department of Cardiology; Department of Cardiac Imaging, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi Arabia
,
M Obadah Kattea
Department of Cardiology; Department of Cardiac Imaging, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi Arabia
,
Sawsan Sayed
Department of Cardiology, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi Arabia
,
Hanaa Saqqah
Department of Cardiac CT Technicians, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi Arabia
,
Mohammed Qintar
Department of Internal Medicine, Cleveland Clinic Foundation Cleveland, OH, USA
,
Osama A Smettei
Department of Cardiology; Department of Cardiac Imaging, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi Arabia
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Abstract

Purpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography. Methods: This study is a single center, cross-sectional study. Eligible patients (n = 159), who under the age of 61 years, with chest pain and mild to moderate probability to have coronary artery disease (CAD) were enrolled. Coronary calcium score and epicardial adipose tissue (EAT) were measured at the level of the left main coronary artery while VAT was measured at the level of the iliac crest. Results: The average age was (48 ± 8 years). The mean VAT was (38 ± 21 cm 2 ) with no significant difference between men and women (38 ± 22 vs. 37 ± 19 P = 0.8) respectively. Student′s t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively. Univariate regression analysis showed that VAT and EAT, are strong predictor for CAC (hazard ratio [HR] 1.034, 95% confidence interval [CI: 1.016-1.052]. P <0.001 and [HR] 1.344, 95% CI: [1.129-1.601] P = 0.001), respectively. Conclusion: Excessive VAT is significantly associated with positive CAC. VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.

Keywords

Computed tomography-angiography - coronary artery calcifications - visceral adipose tissue


Publication History

Article published online:
09 August 2021

© 2015. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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