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CC BY-NC-ND 4.0 · Avicenna J Med 2015; 05(03): 95-97
DOI: 10.4103/2231-0770.160250
CASE REPORT

Tenofovir induced lichenoid drug eruption

Mrinal Gupta
Sudhaa Skin Centre, Jammu, Jammu and Kashmir, India
,
Heena Gupta
Sudhaa Skin Centre, Jammu, Jammu and Kashmir, India
,
Anish Gupta
Acharya Shri Chander College of Medical Sciences, Jammu, Jammu and Kashmir, India
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Abstract

Cutaneous adverse reactions are a common complication of anti-retroviral therapy. Tenofovir is a newer anti-retroviral drug belonging to the nucleotide reverse transcriptase inhibitor group. Systemic adverse effects like nausea, vomiting, diarrhea, hepatotoxicity and renal toxicity are common with tenofovir but cutaneous adverse effects are rare. Lichenoid drug eruptions are a common adverse effect seen with a large variety of drugs including antimalarials, antihypertensives, nonsteroidal anti-inflammatory drugs and diuretics. Lichenoid drug eruption is a rare cutaneous adverse effect of tenofovir with only a single case reported till date. Here, we report a case of tenofovir induced lichenoid drug eruption in a 54-year-old human immunodeficiency virus affected male who presented with generalized lichenoid eruption after 6 weeks of initiation of tenofovir and complete clearance on cessation of the drug.

Keywords

Cutaneous adverse drug reaction - lichenoid drug eruption - tenofovir


Publication History

Article published online:
09 August 2021

© 2015. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Breathnach S. Drug reactions. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook′s Textbook of Dermatology. 8 th ed., Vol. 4. Oxford: Blackwell Science; 2010. p. 73.1-177.
  • 2 Woolley IJ, Veitch AJ, Harangozo CS, Moyle M, Korman TM. Lichenoid drug eruption to tenofovir in an HIV/hepatitis B virus co-infected patient. AIDS 2004;18:1857-8.
  • 3 Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45.
  • 4 The Use of the WHO-UMC System for Standardized Case Causality Assessment [monograph on the Internet]. Uppsala: The Uppsala Monitoring Centre; 2005. Available from: who-umc.org/Graphics/24734.pdf.
  • 5 Majmudar V, Al-Dulaimi H, Dodd H. Lichenoid drug eruption secondary to treatment with nicorandil? Clin Exp Dermatol 2008;33:193-4.
  • 6 Cruz MJ, Duarte AF, Baudrier T, Cunha AP, Barreto F, Azevedo F. Lichenoid drug eruption induced by misoprostol. Contact Dermatitis 2009;61:240-2.
  • 7 Van den Haute V, Antoine JL, Lachapelle JM. Histopathological discriminant criteria between lichenoid drug eruption and idiopathic lichen planus: Retrospective study on selected samples. Dermatologica 1989;179:10-3.
  • 8 Lockhart SM, Rathbun RC, Stephens JR, Baker DL, Drevets DA, Greenfield RA, et al. Cutaneous reactions with tenofovir disoproxil fumarate: A report of nine cases. AIDS 2007;21:1370-3.
  • 9 Verma R, Vasudevan B, Shankar S, Pragasam V, Suwal B, Venugopal R. First reported case of tenofovir-induced photoallergic reaction. Indian J Pharmacol 2012;44:651-3.