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CC BY-NC-ND 4.0 · Avicenna J Med 2015; 05(04): 123-127
DOI: 10.4103/2231-0770.165121
ORIGINAL ARTICLE

Cabergoline for preventing ovarian hyperstimulation syndrome in women at risk undergoingin vitro fertilization/intracytoplasmic sperm injection treatment cycles: A randomized controlled study

Niyazi Kilic
Department of Obstetrics and Gynecology, Suleymaniye Maternity and Children's Teaching and Research Hospital, Istanbul, Turkey
,
Özhan Özdemir
Department of Obstetrics and Gynecology, Ankara Numune Education and Research Hospital, Ankara, Turkey
,
Hakan Cevdet Başar
Department of Obstetrics and Gynecology, Suleymaniye Maternity and Children's Teaching and Research Hospital, Istanbul, Turkey
,
Fadime Demircan
Department of Obstetrics and Gynecology, Suleymaniye Maternity and Children's Teaching and Research Hospital, Istanbul, Turkey
,
Fırat Ekmez
Department of Obstetrics and Gynecology, Suleymaniye Maternity and Children's Teaching and Research Hospital, Istanbul, Turkey
,
Oğuz Yücel
Department of Obstetrics and Gynecology, Suleymaniye Maternity and Children's Teaching and Research Hospital, Istanbul, Turkey
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Background: Ovarian hyperstimulation syndrome (OHSS) is the most serious and potentially life-threatening iatrogenic complication associated with ovarian stimulation during assisted reproductive technology protocols. The aim of this study was to evaluate the role of dopamine agonist as a preventive strategy of OHSS in women at high risk in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles. Methods: Seventy women at risk to develop OHSS undergoing IVF/ICSI treatment cycle were included. The study group received 0.5 mg of cabergoline for 8 days from the day of human chorionic gonadotropin administration in comparison to those who undergo no treatment for the prevention of OHSS. The reduction of the incidence of OHSS was the primary outcome. Results: The actual incidence of OHSS was 8.33% in the cabergoline group and 20.58% in the control group. Thus, the incidence of OHSS was significantly reduced, by almost 60%, in the cabergoline group in comparison with the control group (relative ratios: 0.4, 95% confidence interval: 0.18–0.79). Conclusion: Prophylactic treatment with the dopamine agonist, cabergoline, reduces the incidence of OHSS in women at high risk undergoing IVF/ICSI treatment. However, the effects of cabergoline on important outcomes, namely, live birth, miscarriage, and congenital abnormalities are still uncertain.

Keywords

Cabergoline - ovarian hyperstimulation - vascular endothelial growth factor


Publication History

Article published online:
09 August 2021

© 2015. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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