CC BY-NC-ND 4.0 · South Asian J Cancer 2013; 02(04): 197
DOI: 10.4103/2278-330X.119890
Letter to Editor

The fractionation conundrum: Are we still missing a piece of the puzzle?

Naveen Mummudi
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharahstra, India
,
Sarbani Ghosh Laskar
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharahstra, India
,
J. P. Agarwal
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharahstra, India
› Author Affiliations


Publication History

Article published online:
31 December 2020

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  • References

  • 1 Majumder D, Choudhury K, Das P, Kundu S, Mitra D. Different fractionation schedules of radiotherapy in locally advanced head and neck malignancy: A prospective randomized study to compare the results of treatment and toxicities of different protocols. South Asian J Cancer 2013;2:31-5.
  • 2 Pignon JP, le Maître A, Maillard E, Bourhis J. MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009;92:4-14.
  • 3 Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, et al. Meta-Analysis of Radiotherapy in Carcinomas of Head and neck (MARCH) Collaborative Group. Hyperfractionated or accelerated radiotherapy in head and neck cancer: A meta-analysis. Lancet 2006;368:843-54.
  • 4 Ghosh S, Agarwal JP, Bhutani R, Vora A, Prabhash K, D′cruz A, et al. Randomized Trial of Conventional Fractionated RT (CFRT) vs. Concomitant Chemo Radiotherapy (CTRT) and Accelerated Radiotherapy (ACRT) in Patients With Advanced, Non Nasopharyngeal, Squamous Cell Cancers of the Head and Neck Region. Int J Radiat Oncol Biol Phys 66:S191.
  • 5 Overgaard J, Mohanti BK, Begum N, Ali R, Agarwal JP, Kuddu M, et al. Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (iaea-acc study): A randomised, multicentre trial. Lancet Oncol 2010;11:553-60.
  • 6 Fu KK, Pajak TF, Trotti A, Jones CU, Spencer SA, Phillips TL, et al. A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48:7-16.
  • 7 Bourhis J, Sire C, Graff P, Grégoire V, Maingon P, Calais G, et al. Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): An open-label phase 3 randomised trial. Lancet Oncol 2012;13:145-53.
  • 8 Rishi A, Ghoshal S, Verma R, Oinam AS, Patil VM, Mohinder R, et al. Comparison of concomitant boost radiotherapy against concurrent chemoradiation in locally advanced oropharyngeal cancers: A phase III randomized trial. Radiother Oncol 2013. Jun 6. pii: S0167-8140(13)00231-4 [Epub ahead of print]