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CC BY-NC-ND 4.0 · South Asian J Cancer 2014; 03(01): 066-070
DOI: 10.4103/2278-330X.126531
Review Article

Management of relapsed-refractory diffuse large B cell lymphoma

Lalit S. Raut
Institute of Haematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal
,
Prantar P. Chakrabarti
Institute of Haematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal
› Author Affiliations Source of Support: Nill.
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Abstract

Relapsed-Refractory Diffuse Large B Cell Lymphoma (RR DLBCL), which accounts for approximately one-third of patients with DLBCL, remains a major cause of morbidity and mortality. Managing RR DLBCL continues to be a challenge to the treating hemato-oncologist. Salvage high-dose chemotherapy followed by autologous stem cell transplantation is the standard of care for chemosensitive relapses in DLBCL. Various salvage regimens are available, but the quest for an optimal regimen continues. The addition of rituximab to the salvage regimen has improved the outcome of RR DLBCL. Several pertinent issues regarding the management of RR DLBCL are discussed in this short review.

Key words

Activated B cell - autologous stem cell transplant - diffuse large B cell lymphoma - germinal center B - high dose chemotherapy - relapsed refractory


Publication History

Article published online:
31 December 2020

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